FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938243257> ?p ?o ?g. }

• W2938243257 endingPage "100623" @default.
• W2938243257 startingPage "100623" @default.
• W2938243257 abstract "Lysine (K) type cationic lipid with a propyl spacer and ditetradecyl hydrophobic moieties composing liposomes, K3C14, previously studied for gene delivery, were reported to activate the NLRP3 inflammasomes in human macrophages via the conventional phagolysosomal pathway. In this study, K3C16, a propyl spacer bearing lysine type lipids with dihexadecyl moieties (an extension of two hydrocarbon tail length) were compared with K3C14 as liposomes. Such a small change in tail length did not alter the physical properties such as size distribution, zeta potential and polydispersity index (PDI). The NLRP3 activation potency of K3C16 was shown to be 1.5-fold higher. Yet, the toxicity was minimal, whereas K3C14 has shown to cause significant cell death after 24 h incubation. Even in the presence of endocytosis inhibitors, cytochalasin D or dynasore, K3C16 continued to activate the NLRP3 inflammasomes and to induce IL-1β release. To our surprise, K3C16 liposomes were confirmed to fuse with the plasma membrane of human macrophages and CHO-K1 cells. It is demonstrated that the change in hydrophobic tail length by two hydrocarbons drastically changed a cellular entry route and potency in activating the NLRP3 inflammasomes." @default.
• W2938243257 created "2019-04-25" @default.
• W2938243257 creator A5009349672 @default.
• W2938243257 creator A5015486088 @default.
• W2938243257 creator A5037131620 @default.
• W2938243257 creator A5041897335 @default.
• W2938243257 creator A5047956219 @default.
• W2938243257 creator A5090955304 @default.
• W2938243257 date "2019-07-01" @default.
• W2938243257 modified "2023-10-16" @default.
• W2938243257 title "Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency" @default.
• W2938243257 cites W1967476833 @default.
• W2938243257 cites W1971915082 @default.
• W2938243257 cites W1996087219 @default.
• W2938243257 cites W1996491430 @default.
• W2938243257 cites W2016967864 @default.
• W2938243257 cites W2023287503 @default.
• W2938243257 cites W2034843771 @default.
• W2938243257 cites W2040443361 @default.
• W2938243257 cites W2048032544 @default.
• W2938243257 cites W2069525278 @default.
• W2938243257 cites W2071069136 @default.
• W2938243257 cites W2071404451 @default.
• W2938243257 cites W2083084591 @default.
• W2938243257 cites W2087268320 @default.
• W2938243257 cites W2090859543 @default.
• W2938243257 cites W2126384811 @default.
• W2938243257 cites W2145001648 @default.
• W2938243257 cites W2145190710 @default.
• W2938243257 cites W2154032715 @default.
• W2938243257 cites W2333163768 @default.
• W2938243257 cites W2556863211 @default.
• W2938243257 cites W2767952031 @default.
• W2938243257 cites W2785121620 @default.
• W2938243257 cites W2807953820 @default.
• W2938243257 doi "https://doi.org/10.1016/j.bbrep.2019.100623" @default.
• W2938243257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6462779" @default.
• W2938243257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31011633" @default.
• W2938243257 hasPublicationYear "2019" @default.
• W2938243257 type Work @default.
• W2938243257 sameAs 2938243257 @default.
• W2938243257 citedByCount "6" @default.
• W2938243257 countsByYear W29382432572020 @default.
• W2938243257 countsByYear W29382432572021 @default.
• W2938243257 countsByYear W29382432572022 @default.
• W2938243257 countsByYear W29382432572023 @default.
• W2938243257 crossrefType "journal-article" @default.
• W2938243257 hasAuthorship W2938243257A5009349672 @default.
• W2938243257 hasAuthorship W2938243257A5015486088 @default.
• W2938243257 hasAuthorship W2938243257A5037131620 @default.
• W2938243257 hasAuthorship W2938243257A5041897335 @default.
• W2938243257 hasAuthorship W2938243257A5047956219 @default.
• W2938243257 hasAuthorship W2938243257A5090955304 @default.
• W2938243257 hasBestOaLocation W29382432571 @default.
• W2938243257 hasConcept C12554922 @default.
• W2938243257 hasConcept C1491633281 @default.
• W2938243257 hasConcept C185154212 @default.
• W2938243257 hasConcept C185592680 @default.
• W2938243257 hasConcept C202751555 @default.
• W2938243257 hasConcept C2776016237 @default.
• W2938243257 hasConcept C2779012151 @default.
• W2938243257 hasConcept C28005876 @default.
• W2938243257 hasConcept C515207424 @default.
• W2938243257 hasConcept C55493867 @default.
• W2938243257 hasConcept C57992300 @default.
• W2938243257 hasConcept C86803240 @default.
• W2938243257 hasConcept C95444343 @default.
• W2938243257 hasConceptScore W2938243257C12554922 @default.
• W2938243257 hasConceptScore W2938243257C1491633281 @default.
• W2938243257 hasConceptScore W2938243257C185154212 @default.
• W2938243257 hasConceptScore W2938243257C185592680 @default.
• W2938243257 hasConceptScore W2938243257C202751555 @default.
• W2938243257 hasConceptScore W2938243257C2776016237 @default.
• W2938243257 hasConceptScore W2938243257C2779012151 @default.
• W2938243257 hasConceptScore W2938243257C28005876 @default.
• W2938243257 hasConceptScore W2938243257C515207424 @default.
• W2938243257 hasConceptScore W2938243257C55493867 @default.
• W2938243257 hasConceptScore W2938243257C57992300 @default.
• W2938243257 hasConceptScore W2938243257C86803240 @default.
• W2938243257 hasConceptScore W2938243257C95444343 @default.
• W2938243257 hasFunder F4320320879 @default.
• W2938243257 hasFunder F4320320912 @default.
• W2938243257 hasFunder F4320322638 @default.
• W2938243257 hasFunder F4320334678 @default.
• W2938243257 hasFunder F4320334764 @default.
• W2938243257 hasLocation W29382432571 @default.
• W2938243257 hasLocation W29382432572 @default.
• W2938243257 hasLocation W29382432573 @default.
• W2938243257 hasLocation W29382432574 @default.
• W2938243257 hasOpenAccess W2938243257 @default.
• W2938243257 hasPrimaryLocation W29382432571 @default.
• W2938243257 hasRelatedWork W1638912119 @default.
• W2938243257 hasRelatedWork W1987002621 @default.
• W2938243257 hasRelatedWork W1999729531 @default.
• W2938243257 hasRelatedWork W2004026969 @default.
• W2938243257 hasRelatedWork W2009893540 @default.
• W2938243257 hasRelatedWork W2019858986 @default.
• W2938243257 hasRelatedWork W2045308798 @default.

• next