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- W2938248753 abstract "Since the first giant virus Mimivirus was identified, other giant representatives are isolated regularly around the world and appear to be unique in several aspects. They belong to at least four viral families, and the ways they interact with their hosts remain poorly understood. We focused on Mollivirus sibericum, the sole representative of “Molliviridae,” which was isolated from a 30,000-year-old permafrost sample and exhibits spherical virions of complex composition. In particular, we show that (i) assembly is initiated by a unique structure containing a flat pole positioned at the center of an open cisterna, (ii) core packing involves another cisterna-like element seemingly pushing core proteins into particles being assembled, and (iii) specific filamentous structures contain the viral genome before packaging. Altogether, our findings increase our understanding of how complex giant viruses interact with their host and provide the foundation for future studies to elucidate the molecular mechanisms of Mollivirus assembly." @default.
- W2938248753 created "2019-04-25" @default.
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- W2938248753 date "2019-07-01" @default.
- W2938248753 modified "2023-10-06" @default.
- W2938248753 title "Complex Membrane Remodeling during Virion Assembly of the 30,000-Year-Old Mollivirus Sibericum" @default.
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- W2938248753 doi "https://doi.org/10.1128/jvi.00388-19" @default.
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