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- W2938252246 abstract "We have synthesized a series of compounds based on a piperidyl benzimidazole carboxamide structure, and tested their PARP-1 inhibitory activity, as well as cellular inhibitory activity. Some of them show great potency as PARP-1 inhibitors and antitumor activity, which are valuable for further research. In addition, the predicted ADME properties and proposed binding mode with PARP-1 of the compounds were obtained via computational simulation." @default.
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- W2938252246 date "2020-01-01" @default.
- W2938252246 modified "2023-10-16" @default.
- W2938252246 title "Synthesis and biological evaluation of piperidyl benzimidazole carboxamide derivatives as potent PARP-1 inhibitors and antitumor agents" @default.
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- W2938252246 doi "https://doi.org/10.1016/j.cclet.2019.04.045" @default.
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