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• W2938255449 abstract "The current review provides an updated overview on the role of therapeutic drug monitoring (TDM) of biological therapies in inflammatory bowel disease (IBD). We examine the data behind TDM for the antitumor necrosis factor agents, vedolizumab and ustekinumab, in patients with IBD. In addition, we discuss reactive vs. proactive TDM.There is a positive correlation between biologic drug concentrations and favorable therapeutic outcomes in IBD, although the majority of data refer to antitumor necrosis factor therapy. Reactive TDM has rationalized the management of patients with IBD with loss of response to biological therapy. Moreover, reactive TDM of infliximab has been proven to be more cost-effective when compared with empiric dose optimization. Preliminary data suggest that proactive TDM of infliximab and adalimumab applied in patients with clinical response/remission is associated with better therapeutic outcomes compared with standard of care (empiric treatment and/or reactive TDM).For all biologics in IBD, there is a positive correlation between drug concentrations and favorable therapeutic outcomes. Reactive TDM is the new standard of care for optimizing biologic therapies in IBD, whereas recent data suggest an important role of proactive TDM for optimizing antitumor necrosis factor therapy in IBD." @default.
• W2938255449 created "2019-04-25" @default.
• W2938255449 creator A5060108766 @default.
• W2938255449 creator A5078196032 @default.
• W2938255449 date "2019-07-01" @default.
• W2938255449 modified "2023-10-18" @default.
• W2938255449 title "Therapeutic drug monitoring in inflammatory bowel disease" @default.
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• W2938255449 doi "https://doi.org/10.1097/mog.0000000000000536" @default.
• W2938255449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6785387" @default.
• W2938255449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30973355" @default.
• W2938255449 hasPublicationYear "2019" @default.
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