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- W2938260764 endingPage "175628481984274" @default.
- W2938260764 startingPage "175628481984274" @default.
- W2938260764 abstract "Background: Biological therapy has revolutionized the treatment of inflammatory bowel disease (IBD). After the expiration of patents for biological innovator products, development of biosimilars increased. CT-P13 was the first biosimilar approved for the same indications as the reference product; however, the approval was based on extrapolated data from rheumatoid arthritis and ankylosing spondylitis. Our aim was to review clinical studies about switching from originator infliximab (IFX-O) to biosimilar infliximab (IXF-B) in IBD, focusing on recently published data and the future of biosimilars. Methods: The PubMed database was searched for original articles published up to 1 December 2018 reporting data on IFX-B in IBD. Results: A total of 29 studies assessing switching from IFX-O to IFX-B, 14 assessing induction therapy with IFX-B were found. Efficacy, safety and immunogenicity were discussed. Studies confirm that CT-P13 is safe and equally efficient as the reference product for both induction and maintenance therapy; and that switching from the reference product to biosimilar is non-inferior to continuous biosimilar use. However, efficacy and safety data on Flixabi (SB2) in IBD patients is lacking. Conclusion: Switching from the originator to a biosimilar in patients with IBD is acceptable, although scientific and clinical evidence is lacking regarding reverse switching, multiple switching and cross-switching among biosimilars in IBD patients." @default.
- W2938260764 created "2019-04-25" @default.
- W2938260764 creator A5017480366 @default.
- W2938260764 creator A5037242507 @default.
- W2938260764 creator A5082236738 @default.
- W2938260764 date "2019-01-01" @default.
- W2938260764 modified "2023-09-25" @default.
- W2938260764 title "Switching from infliximab to biosimilar in inflammatory bowel disease: overview of the literature and perspective" @default.
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- W2938260764 doi "https://doi.org/10.1177/1756284819842748" @default.
- W2938260764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6469269" @default.
- W2938260764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31019554" @default.
- W2938260764 hasPublicationYear "2019" @default.
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