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- W2938262053 abstract "During tablet manufacturing, as the powder is compressed, it sometimes adheres to the tablet punches. It can be a significant obstacle to tablet manufacturing efficiency, product quality, and result in financial impact with the loss of active pharmaceutical ingredient, drug product, and production time. Punch picking is a type of adherence that is observed around the punch debossing that leads to a pitted tablet surface. This chapter discusses picking and sticking under the overarching topic of punch sticking during tablet compression. Compression refers to the reduction in powder volume during formation of a compact or tablet of certain tensile strength. Punch sticking results from variables within three main factors: formulation, engineering/manufacturing equipment, and environmental conditions. Takeoff force is the amount of energy necessary to remove a tablet from the bottom punch after compression. The three environmental factors of moisture, temperature, and electrostatic forces are external to formulations and equipment." @default.
- W2938262053 created "2019-04-25" @default.
- W2938262053 creator A5023485429 @default.
- W2938262053 date "2019-03-29" @default.
- W2938262053 modified "2023-10-16" @default.
- W2938262053 title "PUNCH STICKING" @default.
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- W2938262053 doi "https://doi.org/10.1002/9781119600800.ch60" @default.
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