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- W2938263335 abstract "Artificial cells can shed new light on the molecular basis for life and hold potential for new chemical technologies. Inspired by how nature dynamically regulates its membrane compartments, we aim to repurpose the endosomal sorting complex required for transport (ESCRT) to generate complex membrane architectures as suitable scaffolds for artificial cells. Purified ESCRT-III components perform topological transformations on giant unilamellar vesicles to create complex “vesicles-within-a-vesicle” architectures resembling the compartmentalization in eukaryotic cells. Thus far, the proposed mechanisms for this activity are based on how assembly and disassembly of ESCRT-III on the membrane drives deformation. Here we demonstrate the existence of a negative feedback mechanism from membrane mechanics that regulates ESCRT-III remodeling activity. Intraluminal vesicle (ILV) formation removes excess membrane area, increasing tension, which in turn suppresses downstream ILV formation. This mechanism for in vitro regulation of ESCRT-III activity may also have important implications for its in vivo functions." @default.
- W2938263335 created "2019-04-25" @default.
- W2938263335 creator A5044660373 @default.
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- W2938263335 date "2019-05-01" @default.
- W2938263335 modified "2023-10-18" @default.
- W2938263335 title "In Vitro Membrane Remodeling by ESCRT is Regulated by Negative Feedback from Membrane Tension" @default.
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- W2938263335 doi "https://doi.org/10.1016/j.isci.2019.04.021" @default.
- W2938263335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6503128" @default.
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