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• W2938266875 endingPage "1723" @default.
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• W2938266875 abstract "The relation between taste perception, diet, and adiposity remains controversial. Additionally, there is a lack of knowledge on the polymorphisms influencing taste given the scarcity of genome-wide association studies (GWASs) published. We studied the relation between perception of the basic tastes, i.e., sweet, salty, bitter, sour, and umami (separately and jointly in a “taste score”), and anthropometric measurements in older subjects with metabolic syndrome (MetS). GWASs were undertaken to identify genes associated with basic tastes and their score. Taste perception was cross-sectionally determined by challenging subjects (381 older individuals with MetS) with solutions (5 concentrations) of the basic tastes with the use of standard prototypical tastants (phenylthiocarbamide and 6-n-propylthiouracil, NaCl, sucrose, monopotassium glutamate, and citric acid, for bitter, salt, sweet, umami, and sour, respectively). Taste perception intensities were expressed on a scale. A total taste score was derived. The total taste score was inversely associated with body weight, body mass index, and waist circumference (P < 0.05). Subjects having a total taste score higher than or equal to the median (11 points for concentration V) were less likely to be classified as obese than subjects below the median (OR: 0.36; 95% CI: 0.22, 0.59; P < 0.001). Associations were similar, albeit less strong, for some taste qualities. In the GWASs, the highest associations were for bitter taste (rs1726866-TAS2R38, with P = 7.74 × 10−18 for phenylthiocarbamide and P = 3.96 × 10−19 for 6-n-propylthiouracil). For other tastes, several single-nucleotide polymorphisms (SNPs) exceeded the P threshold of 1 × 10−5. However, the top-ranked SNPs independently explained a low percentage of taste variability, hence their use as single proxies for the association between taste perception and adiposity is limited. We found a strong inverse association between greater taste perception and body weight, body mass index, and waist circumference in older subjects with MetS and identified some taste-related SNPs. It would be advantageous to identify additional genetic proxies for taste and to develop polygenic scores. Data used in this study were derived from the clinical trial PREDIMED PLUS at baseline, registered at http://www.isrctn.com as ISRCTN89898870." @default.
• W2938266875 created "2019-04-25" @default.
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• W2938266875 date "2019-06-01" @default.
• W2938266875 modified "2023-10-15" @default.
• W2938266875 title "Association between taste perception and adiposity in overweight or obese older subjects with metabolic syndrome and identification of novel taste-related genes" @default.
• W2938266875 cites W1484619102 @default.
• W2938266875 cites W1965914966 @default.
• W2938266875 cites W1976778744 @default.
• W2938266875 cites W1985101496 @default.
• W2938266875 cites W1989696032 @default.
• W2938266875 cites W1993464077 @default.
• W2938266875 cites W1994306508 @default.
• W2938266875 cites W2006854902 @default.
• W2938266875 cites W2010639321 @default.
• W2938266875 cites W2011104796 @default.
• W2938266875 cites W2013842240 @default.
• W2938266875 cites W2014805268 @default.
• W2938266875 cites W2021558267 @default.
• W2938266875 cites W2024603206 @default.
• W2938266875 cites W2024663185 @default.
• W2938266875 cites W2032922016 @default.
• W2938266875 cites W2033853916 @default.
• W2938266875 cites W2041777433 @default.
• W2938266875 cites W2053300511 @default.
• W2938266875 cites W2058222154 @default.
• W2938266875 cites W2061534557 @default.
• W2938266875 cites W2068896031 @default.
• W2938266875 cites W2070355966 @default.
• W2938266875 cites W2080314427 @default.
• W2938266875 cites W2088014312 @default.
• W2938266875 cites W2097504691 @default.
• W2938266875 cites W2099085143 @default.
• W2938266875 cites W2104474719 @default.
• W2938266875 cites W2108903976 @default.
• W2938266875 cites W2110949192 @default.
• W2938266875 cites W2115290889 @default.
• W2938266875 cites W2121123417 @default.
• W2938266875 cites W2126068212 @default.
• W2938266875 cites W2129682733 @default.
• W2938266875 cites W2131255459 @default.
• W2938266875 cites W2140405768 @default.
• W2938266875 cites W2141820415 @default.
• W2938266875 cites W2143104968 @default.
• W2938266875 cites W2145126181 @default.
• W2938266875 cites W2148298325 @default.
• W2938266875 cites W2161286259 @default.
• W2938266875 cites W2161633633 @default.
• W2938266875 cites W2162530578 @default.
• W2938266875 cites W2169795817 @default.
• W2938266875 cites W2170769952 @default.
• W2938266875 cites W2259300265 @default.
• W2938266875 cites W2282361196 @default.
• W2938266875 cites W2287578227 @default.
• W2938266875 cites W2325639215 @default.
• W2938266875 cites W2338280958 @default.
• W2938266875 cites W2344344433 @default.
• W2938266875 cites W2346645055 @default.
• W2938266875 cites W2409570697 @default.
• W2938266875 cites W2463214130 @default.
• W2938266875 cites W2468797166 @default.
• W2938266875 cites W2522990545 @default.
• W2938266875 cites W2553234582 @default.
• W2938266875 cites W2554528991 @default.
• W2938266875 cites W2563625804 @default.
• W2938266875 cites W2576316547 @default.
• W2938266875 cites W2583989441 @default.
• W2938266875 cites W2589961401 @default.
• W2938266875 cites W2592633296 @default.
• W2938266875 cites W2593839008 @default.
• W2938266875 cites W2594843069 @default.
• W2938266875 cites W2619016425 @default.
• W2938266875 cites W2622193319 @default.
• W2938266875 cites W2624447332 @default.
• W2938266875 cites W2643153130 @default.
• W2938266875 cites W2731177171 @default.
• W2938266875 cites W2738590555 @default.
• W2938266875 cites W2742678630 @default.
• W2938266875 cites W2742748694 @default.
• W2938266875 cites W2743767942 @default.
• W2938266875 cites W2743929579 @default.
• W2938266875 cites W2762357481 @default.
• W2938266875 cites W2765867889 @default.
• W2938266875 cites W2768238915 @default.
• W2938266875 cites W2773900121 @default.
• W2938266875 cites W2786500876 @default.
• W2938266875 cites W2793253965 @default.

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