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• W2938285217 abstract "Anti-tumorigenic vs pro-tumorigenic roles of estrogen receptor-beta (ESR2) in breast cancer remain unsettled. We investigated the potential of TP53 status to be a determinant of the bi-faceted role of ESR2 and associated therapeutic implications for triple negative breast cancer (TNBC).ESR2-TP53 interaction was analyzed with multiple assays including the in situ proximity ligation assay. Transcriptional effects on TP53-target genes and cell proliferation in response to knocking down or overexpressing ESR2 were determined. Patient survival according to ESR2 expression levels and TP53 mutation status was analyzed in the basal-like TNBC subgroup in the Molecular Taxonomy of Breast Cancer International Consortium (n = 308) and Roswell Park Comprehensive Cancer Center (n = 46) patient cohorts by univariate Cox regression and log-rank test. All statistical tests are two-sided.ESR2 interaction with wild-type and mutant TP53 caused pro-proliferative and anti-proliferative effects, respectively. Depleting ESR2 in cells expressing wild-type TP53 resulted in increased expression of TP53-target genes CDKN1A (control group mean [SD] = 1 [0.13] vs ESR2 depletion group mean [SD] = 2.08 [0.24], P = .003) and BBC3 (control group mean [SD] = 1 [0.06] vs ESR2 depleted group mean [SD] = 1.92 [0.25], P = .003); however, expression of CDKN1A (control group mean [SD] = 1 [0.21] vs ESR2 depleted group mean [SD] = 0.56 [0.12], P = .02) and BBC3 (control group mean [SD] = 1 [0.03] vs ESR2 depleted group mean [SD] = 0.55 [0.09], P = .008) was decreased in cells expressing mutant TP53. Overexpressing ESR2 had opposite effects. Tamoxifen increased ESR2-mutant TP53 interaction, leading to reactivation of TP73 and apoptosis. High levels of ESR2 expression in mutant TP53-expressing basal-like tumors is associated with better prognosis (Molecular Taxonomy of Breast Cancer International Consortium cohort: log-rank P = .001; hazard ratio = 0.26, 95% confidence interval = 0.08 to 0.84, univariate Cox P = .02).TP53 status is a determinant of the functional duality of ESR2. Our study suggests that ESR2-mutant TP53 combination prognosticates survival in TNBC revealing a novel strategy to stratify TNBC for therapeutic intervention potentially by repurposing tamoxifen." @default.
• W2938285217 created "2019-04-25" @default.
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• W2938285217 date "2019-04-16" @default.
• W2938285217 modified "2023-09-30" @default.
• W2938285217 title "TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer" @default.
• W2938285217 cites W1556144459 @default.
• W2938285217 cites W1828641367 @default.
• W2938285217 cites W1900170853 @default.
• W2938285217 cites W1937707692 @default.
• W2938285217 cites W1971274526 @default.
• W2938285217 cites W1972228847 @default.
• W2938285217 cites W1984996767 @default.
• W2938285217 cites W1985064409 @default.
• W2938285217 cites W1987608812 @default.
• W2938285217 cites W1992496728 @default.
• W2938285217 cites W1995821399 @default.
• W2938285217 cites W1997402112 @default.
• W2938285217 cites W1998559412 @default.
• W2938285217 cites W2003685376 @default.
• W2938285217 cites W2004083214 @default.
• W2938285217 cites W2005563089 @default.
• W2938285217 cites W2005895632 @default.
• W2938285217 cites W2016908879 @default.
• W2938285217 cites W2019413329 @default.
• W2938285217 cites W2020508605 @default.
• W2938285217 cites W2024143289 @default.
• W2938285217 cites W2024996523 @default.
• W2938285217 cites W2025494132 @default.
• W2938285217 cites W2033737920 @default.
• W2938285217 cites W2034329552 @default.
• W2938285217 cites W2035435589 @default.
• W2938285217 cites W2039359938 @default.
• W2938285217 cites W2041929955 @default.
• W2938285217 cites W2053385718 @default.
• W2938285217 cites W2057391792 @default.
• W2938285217 cites W2063382533 @default.
• W2938285217 cites W2069452349 @default.
• W2938285217 cites W2072544833 @default.
• W2938285217 cites W2077655442 @default.
• W2938285217 cites W2079637722 @default.
• W2938285217 cites W2079769807 @default.
• W2938285217 cites W2081572818 @default.
• W2938285217 cites W2083426370 @default.
• W2938285217 cites W2084708321 @default.
• W2938285217 cites W2084831115 @default.
• W2938285217 cites W2089094422 @default.
• W2938285217 cites W2091084179 @default.
• W2938285217 cites W2092736138 @default.
• W2938285217 cites W2094420610 @default.
• W2938285217 cites W2098524712 @default.
• W2938285217 cites W2101063496 @default.
• W2938285217 cites W2104296738 @default.
• W2938285217 cites W2112396116 @default.
• W2938285217 cites W2126982762 @default.
• W2938285217 cites W2128321558 @default.
• W2938285217 cites W2133010239 @default.
• W2938285217 cites W2137628089 @default.
• W2938285217 cites W2138068224 @default.
• W2938285217 cites W2139986038 @default.
• W2938285217 cites W2141280707 @default.
• W2938285217 cites W2141349182 @default.
• W2938285217 cites W2141563900 @default.
• W2938285217 cites W2143001644 @default.
• W2938285217 cites W2146792947 @default.
• W2938285217 cites W2151301267 @default.
• W2938285217 cites W2153298622 @default.
• W2938285217 cites W2155988062 @default.
• W2938285217 cites W2166766053 @default.
• W2938285217 cites W2166869851 @default.
• W2938285217 cites W2170366015 @default.
• W2938285217 cites W2226544481 @default.
• W2938285217 cites W2254691920 @default.
• W2938285217 cites W2262334224 @default.
• W2938285217 cites W2267686699 @default.
• W2938285217 cites W2293040502 @default.
• W2938285217 cites W2322292363 @default.
• W2938285217 cites W2375577403 @default.
• W2938285217 cites W2479426178 @default.
• W2938285217 cites W2511481511 @default.

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