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- W2938288315 startingPage "1462" @default.
- W2938288315 abstract "Abstract Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre‐lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI‐rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI‐rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI‐rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis." @default.
- W2938288315 created "2019-04-25" @default.
- W2938288315 creator A5000642361 @default.
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- W2938288315 date "2019-04-16" @default.
- W2938288315 modified "2023-10-14" @default.
- W2938288315 title "Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain" @default.
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- W2938288315 doi "https://doi.org/10.1002/glia.23620" @default.
- W2938288315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6790715" @default.
- W2938288315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30989733" @default.
- W2938288315 hasPublicationYear "2019" @default.