Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938348727> ?p ?o ?g. }
- W2938348727 endingPage "1958" @default.
- W2938348727 startingPage "1953" @default.
- W2938348727 abstract "Accumulation of filamentous aggregates of α-synuclein (AS) in Lewy bodies and neurites is characteristic of neurodegenerative diseases such as Parkinson's disease. Inhibition of AS fibrillation is helpful for understanding of AS aggregate structure and for developing chemical therapies. Herein, we report that the PtII -containing antitumor drug cisplatin suppresses filamentous aggregation of AS in solution. PtII thus contrasts strongly with reported transition-metal ions such as MnII , FeIII , and CuII , which accelerate AS aggregation. Interaction between PtII and the side chains of methionine and histidine residues was essential for inhibition of AS fibrillation. Binding of PtII to AS did not change the protein's overall random coil structure, as indicated by solution-state two-dimensional NMR and circular dichroism spectroscopy; and a solution of the AS⋅PtII complex remained free of filamentous aggregates. Our results constitute interesting new information about the biological chemistry of metal ions in Parkinson's disease and might open new lines of research into the suppression of filamentous aggregation." @default.
- W2938348727 created "2019-04-25" @default.
- W2938348727 creator A5001573736 @default.
- W2938348727 creator A5025728346 @default.
- W2938348727 creator A5030312735 @default.
- W2938348727 creator A5032938196 @default.
- W2938348727 creator A5068670108 @default.
- W2938348727 date "2019-06-26" @default.
- W2938348727 modified "2023-09-24" @default.
- W2938348727 title "Coordination of Platinum to α‐Synuclein Inhibits Filamentous Aggregation in Solution" @default.
- W2938348727 cites W1521854746 @default.
- W2938348727 cites W1548866259 @default.
- W2938348727 cites W1680110353 @default.
- W2938348727 cites W1753952923 @default.
- W2938348727 cites W1965095016 @default.
- W2938348727 cites W1968942251 @default.
- W2938348727 cites W1974693247 @default.
- W2938348727 cites W1975188689 @default.
- W2938348727 cites W1978649563 @default.
- W2938348727 cites W1980034942 @default.
- W2938348727 cites W1990004798 @default.
- W2938348727 cites W1994939101 @default.
- W2938348727 cites W2001916137 @default.
- W2938348727 cites W2017030176 @default.
- W2938348727 cites W2022173743 @default.
- W2938348727 cites W2022654678 @default.
- W2938348727 cites W2026606393 @default.
- W2938348727 cites W2027511460 @default.
- W2938348727 cites W2027783821 @default.
- W2938348727 cites W2032392617 @default.
- W2938348727 cites W2033938955 @default.
- W2938348727 cites W2054698767 @default.
- W2938348727 cites W2056627673 @default.
- W2938348727 cites W2057567541 @default.
- W2938348727 cites W2062293552 @default.
- W2938348727 cites W2077044335 @default.
- W2938348727 cites W2084929273 @default.
- W2938348727 cites W2085137396 @default.
- W2938348727 cites W2089435862 @default.
- W2938348727 cites W2089522371 @default.
- W2938348727 cites W2102604361 @default.
- W2938348727 cites W2105973889 @default.
- W2938348727 cites W2110824216 @default.
- W2938348727 cites W2114611012 @default.
- W2938348727 cites W2116645442 @default.
- W2938348727 cites W2116835748 @default.
- W2938348727 cites W2117726740 @default.
- W2938348727 cites W2125586800 @default.
- W2938348727 cites W2125751506 @default.
- W2938348727 cites W2137791190 @default.
- W2938348727 cites W2138070282 @default.
- W2938348727 cites W2148225540 @default.
- W2938348727 cites W2154010267 @default.
- W2938348727 cites W2158977717 @default.
- W2938348727 cites W2164385197 @default.
- W2938348727 cites W2268202063 @default.
- W2938348727 cites W2317462515 @default.
- W2938348727 cites W2319105802 @default.
- W2938348727 cites W2320730526 @default.
- W2938348727 cites W2329266664 @default.
- W2938348727 cites W2345979337 @default.
- W2938348727 cites W2423208326 @default.
- W2938348727 cites W2571594992 @default.
- W2938348727 cites W2588887021 @default.
- W2938348727 cites W2603410215 @default.
- W2938348727 cites W2747709233 @default.
- W2938348727 cites W2793431243 @default.
- W2938348727 cites W2885863704 @default.
- W2938348727 cites W2889082939 @default.
- W2938348727 cites W2893729429 @default.
- W2938348727 cites W4233649406 @default.
- W2938348727 cites W4234378353 @default.
- W2938348727 cites W4250279626 @default.
- W2938348727 cites W4255308928 @default.
- W2938348727 doi "https://doi.org/10.1002/cbic.201900224" @default.
- W2938348727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30958607" @default.
- W2938348727 hasPublicationYear "2019" @default.
- W2938348727 type Work @default.
- W2938348727 sameAs 2938348727 @default.
- W2938348727 citedByCount "5" @default.
- W2938348727 countsByYear W29383487272021 @default.
- W2938348727 countsByYear W29383487272022 @default.
- W2938348727 countsByYear W29383487272023 @default.
- W2938348727 crossrefType "journal-article" @default.
- W2938348727 hasAuthorship W2938348727A5001573736 @default.
- W2938348727 hasAuthorship W2938348727A5025728346 @default.
- W2938348727 hasAuthorship W2938348727A5030312735 @default.
- W2938348727 hasAuthorship W2938348727A5032938196 @default.
- W2938348727 hasAuthorship W2938348727A5068670108 @default.
- W2938348727 hasConcept C12554922 @default.
- W2938348727 hasConcept C133571119 @default.
- W2938348727 hasConcept C136238340 @default.
- W2938348727 hasConcept C142724271 @default.
- W2938348727 hasConcept C161790260 @default.
- W2938348727 hasConcept C185592680 @default.
- W2938348727 hasConcept C21951064 @default.
- W2938348727 hasConcept C27523624 @default.
- W2938348727 hasConcept C2779097696 @default.