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- W2938353995 abstract "It is common to evaluate the mechanical performance of a tissue-engineered construct using concepts from linear elasticity theory, or variations thereof, and uniaxial testing data. In some cases the non-linear nature of tissue stress-strain behavior has prompted development of empirical approaches to obtain a more comprehensive description of the observed mechanical behavior. Such approaches constitute improvements over singular stiffness measures but the lack of an appropriate non-linear theoretical foundation renders them somewhat arbitrary and potentially incomplete. Recently, a theoretical mechanics framework for non-linear tissues was developed based on first principles in physics. The Freed-Rajagopal 1-D Fiber Model incorporates physically meaningful parameters that provide a unique and comprehensive characterization of non-linear tissue behavior. The physical interpretation of these parameters provides intuitive insight suggesting they may serve as important design targets for tissue engineering applications. In this study, the Freed-Rajagopal model was employed with conventional uniaxial mechanical testing data obtained from experiments with tissue-engineered hernia repair grafts and the healthy native tissue counterpart. Results from the Freed-Rajagopal analysis revealed that tissue-engineered constructs that qualify as biomimetic according to linear elasticity theory, or variations thereof, are not truly biomimetic, as they do not exhibit the non-linear mechanical behaviors observed in their native tissue counterparts. Most importantly, the Freed-Rajagopal model was easy to employ and revealed specific design improvements that could be targeted to improve the biofidelity of these constructs. A performance comparison with conventional non-linear models was then conducted and revealed the Freed-Rajagopal model produced results the correlated exceptionally well with experimental data." @default.
- W2938353995 created "2019-04-25" @default.
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- W2938353995 date "2019-03-01" @default.
- W2938353995 modified "2023-09-23" @default.
- W2938353995 title "A Practical Approach for Characterizing the Non-Linear Mechanical Behavior of Native and Engineered Tissues Using a New Theoretical Framework That Incorporates Intuitive Physically Meaningful Parameters" @default.
- W2938353995 hasPublicationYear "2019" @default.
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