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- W2938366281 startingPage "726" @default.
- W2938366281 abstract "Senescent cells have undergone permanent growth arrest, adopt an altered secretory phenotype, and accumulate in the kidney and other organs with ageing and injury. Senescence has diverse physiologic roles and experimental studies support its importance in nephrogenesis, successful tissue repair, and in opposing malignant transformation. However, recent murine studies have shown that depletion of chronically senescent cells extends healthy lifespan and delays age-associated disease—implicating senescence and the senescence-associated secretory phenotype as drivers of organ dysfunction. Great interest is therefore focused on the manipulation of senescence as a novel therapeutic target in kidney disease. In this review, we examine current knowledge and areas of ongoing uncertainty regarding senescence in the human kidney and experimental models. We summarize evidence supporting the role of senescence in normal kidney development and homeostasis but also senescence-induced maladaptive repair, renal fibrosis, and transplant failure. Recent studies using senescent cell manipulation and depletion as novel therapies to treat renal disease are discussed, and we explore unanswered questions for future research." @default.
- W2938366281 created "2019-04-25" @default.
- W2938366281 creator A5006239088 @default.
- W2938366281 creator A5030110805 @default.
- W2938366281 creator A5087532153 @default.
- W2938366281 creator A5089781525 @default.
- W2938366281 date "2019-04-18" @default.
- W2938366281 modified "2023-10-16" @default.
- W2938366281 title "Cellular Senescence in the Kidney" @default.
- W2938366281 cites W1504176593 @default.
- W2938366281 cites W1504396908 @default.
- W2938366281 cites W1932046626 @default.
- W2938366281 cites W1940386026 @default.
- W2938366281 cites W1965699247 @default.
- W2938366281 cites W1969252550 @default.
- W2938366281 cites W1970891016 @default.
- W2938366281 cites W1970924670 @default.
- W2938366281 cites W1973886069 @default.
- W2938366281 cites W1973959559 @default.
- W2938366281 cites W1976635482 @default.
- W2938366281 cites W1977362098 @default.
- W2938366281 cites W1982445841 @default.
- W2938366281 cites W1982763980 @default.
- W2938366281 cites W1986594019 @default.
- W2938366281 cites W1988233144 @default.
- W2938366281 cites W1999265533 @default.
- W2938366281 cites W2001720505 @default.
- W2938366281 cites W2004314923 @default.
- W2938366281 cites W2004809264 @default.
- W2938366281 cites W2010417927 @default.
- W2938366281 cites W2025128236 @default.
- W2938366281 cites W2034163612 @default.
- W2938366281 cites W2038076787 @default.
- W2938366281 cites W2042140414 @default.
- W2938366281 cites W2044341880 @default.
- W2938366281 cites W2047119143 @default.
- W2938366281 cites W2050393640 @default.
- W2938366281 cites W2051981338 @default.
- W2938366281 cites W2052388837 @default.
- W2938366281 cites W2054995008 @default.
- W2938366281 cites W2061765285 @default.
- W2938366281 cites W2065183391 @default.
- W2938366281 cites W2069519394 @default.
- W2938366281 cites W2072949762 @default.
- W2938366281 cites W2082068395 @default.
- W2938366281 cites W2088503775 @default.
- W2938366281 cites W2090067193 @default.
- W2938366281 cites W2102774255 @default.
- W2938366281 cites W2108273756 @default.
- W2938366281 cites W2108592175 @default.
- W2938366281 cites W2108887402 @default.
- W2938366281 cites W2116435487 @default.
- W2938366281 cites W2119316461 @default.
- W2938366281 cites W2123104757 @default.
- W2938366281 cites W2124167732 @default.
- W2938366281 cites W2126709547 @default.
- W2938366281 cites W2128668256 @default.
- W2938366281 cites W2128807350 @default.
- W2938366281 cites W2130458932 @default.
- W2938366281 cites W2131078803 @default.
- W2938366281 cites W2132224453 @default.
- W2938366281 cites W2132716349 @default.
- W2938366281 cites W2137422851 @default.
- W2938366281 cites W2146176842 @default.
- W2938366281 cites W2148768345 @default.
- W2938366281 cites W2149358482 @default.
- W2938366281 cites W2150748567 @default.
- W2938366281 cites W2156648257 @default.
- W2938366281 cites W2156935689 @default.
- W2938366281 cites W2157712321 @default.
- W2938366281 cites W2193792657 @default.
- W2938366281 cites W2210634983 @default.
- W2938366281 cites W2224886002 @default.
- W2938366281 cites W2266290735 @default.
- W2938366281 cites W2304048947 @default.
- W2938366281 cites W2326298762 @default.
- W2938366281 cites W2416051724 @default.
- W2938366281 cites W2438502441 @default.
- W2938366281 cites W2521666083 @default.
- W2938366281 cites W2538566894 @default.
- W2938366281 cites W2555998158 @default.
- W2938366281 cites W2599353531 @default.
- W2938366281 cites W2604477713 @default.
- W2938366281 cites W2608899726 @default.
- W2938366281 cites W2616605368 @default.
- W2938366281 cites W2766773965 @default.
- W2938366281 cites W2773432877 @default.
- W2938366281 cites W2774297193 @default.
- W2938366281 cites W2805184558 @default.
- W2938366281 cites W2806846414 @default.
- W2938366281 cites W2855985248 @default.
- W2938366281 cites W2860743873 @default.
- W2938366281 cites W2884647648 @default.
- W2938366281 cites W2888014098 @default.
- W2938366281 cites W2890873793 @default.
- W2938366281 cites W2893296950 @default.
- W2938366281 cites W2904519862 @default.
- W2938366281 cites W2912968970 @default.