FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938371473> ?p ?o ?g. }

• W2938371473 endingPage "e0215237" @default.
• W2938371473 startingPage "e0215237" @default.
• W2938371473 abstract "We investigated the significance of MUC21 in EGFR-mutated lung adenocarcinoma (LADC). Two-hundred forty-one surgically resected LADCs (116 EGFR-mutated and 125 wild-type tumors) were examined for immunohistochemical expression of MUC21 protein. A polyclonal antibody and two monoclonal antibodies (heM21C and heM21D) that bind differentially glycosylated MUC21 epitopes were used, and MUC21 proteins detected by these antibodies were named MUC21P, MUC21C, and MUC21D, respectively. MUC21 mRNA levels were semi-quantified and classified into high and low. Among the immunohistochemical expression detected by three different antibodies, high expressors tended to be related to EGFR mutations. The three varieties of the immunohistochemical expressions were related to different histological elements in the EGFR-mutated LADCs. Either MUC21P or MUC21C high expressors had a higher proportion of lepidic elements with low papillary structure and micropapillary elements. MUC21D high expressors had a significantly higher proportion of micropapillary elements (Mann-Whitney test P ≤0.0001). Furthermore, MUC21D high expressors showed high incidence of lymphatic canal invasion and lymph node metastasis (Pearson x2 test, P = 0.0021, P = 0.0125), and a significantly higher recurrence rate (5-year recurrence-free survival 50.7% vs. 73.8%, log-rank test P = 0.0495). MUC21 proteins with a specific glycosylation status may be involved in the progression of EGFR-mutated LADCs, particularly at the stage where tumors are transforming from pure lepidic to micropapillary through low papillary lepidic lesions." @default.
• W2938371473 created "2019-04-25" @default.
• W2938371473 creator A5007714565 @default.
• W2938371473 creator A5012053583 @default.
• W2938371473 creator A5014368516 @default.
• W2938371473 creator A5015284623 @default.
• W2938371473 creator A5022602325 @default.
• W2938371473 creator A5024814792 @default.
• W2938371473 creator A5041864474 @default.
• W2938371473 creator A5053599485 @default.
• W2938371473 creator A5059623116 @default.
• W2938371473 creator A5065613884 @default.
• W2938371473 creator A5069736501 @default.
• W2938371473 creator A5081556748 @default.
• W2938371473 creator A5084988611 @default.
• W2938371473 date "2019-04-11" @default.
• W2938371473 modified "2023-09-25" @default.
• W2938371473 title "Specific expression of MUC21 in micropapillary elements of lung adenocarcinomas – Implications for the progression of EGFR-mutated lung adenocarcinomas" @default.
• W2938371473 cites W1966774423 @default.
• W2938371473 cites W2002173301 @default.
• W2938371473 cites W2022471636 @default.
• W2938371473 cites W2033652720 @default.
• W2938371473 cites W2037096088 @default.
• W2938371473 cites W2050650103 @default.
• W2938371473 cites W2057049168 @default.
• W2938371473 cites W2100654610 @default.
• W2938371473 cites W2112551904 @default.
• W2938371473 cites W2125357068 @default.
• W2938371473 cites W2147711212 @default.
• W2938371473 cites W2314681666 @default.
• W2938371473 cites W2323499669 @default.
• W2938371473 cites W2554832819 @default.
• W2938371473 cites W2897423476 @default.
• W2938371473 doi "https://doi.org/10.1371/journal.pone.0215237" @default.
• W2938371473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6459478" @default.
• W2938371473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30973916" @default.
• W2938371473 hasPublicationYear "2019" @default.
• W2938371473 type Work @default.
• W2938371473 sameAs 2938371473 @default.
• W2938371473 citedByCount "8" @default.
• W2938371473 countsByYear W29383714732021 @default.
• W2938371473 countsByYear W29383714732022 @default.
• W2938371473 crossrefType "journal-article" @default.
• W2938371473 hasAuthorship W2938371473A5007714565 @default.
• W2938371473 hasAuthorship W2938371473A5012053583 @default.
• W2938371473 hasAuthorship W2938371473A5014368516 @default.
• W2938371473 hasAuthorship W2938371473A5015284623 @default.
• W2938371473 hasAuthorship W2938371473A5022602325 @default.
• W2938371473 hasAuthorship W2938371473A5024814792 @default.
• W2938371473 hasAuthorship W2938371473A5041864474 @default.
• W2938371473 hasAuthorship W2938371473A5053599485 @default.
• W2938371473 hasAuthorship W2938371473A5059623116 @default.
• W2938371473 hasAuthorship W2938371473A5065613884 @default.
• W2938371473 hasAuthorship W2938371473A5069736501 @default.
• W2938371473 hasAuthorship W2938371473A5081556748 @default.
• W2938371473 hasAuthorship W2938371473A5084988611 @default.
• W2938371473 hasBestOaLocation W29383714731 @default.
• W2938371473 hasConcept C121608353 @default.
• W2938371473 hasConcept C126322002 @default.
• W2938371473 hasConcept C142724271 @default.
• W2938371473 hasConcept C159654299 @default.
• W2938371473 hasConcept C203014093 @default.
• W2938371473 hasConcept C204232928 @default.
• W2938371473 hasConcept C2777714996 @default.
• W2938371473 hasConcept C2781182431 @default.
• W2938371473 hasConcept C502942594 @default.
• W2938371473 hasConcept C71924100 @default.
• W2938371473 hasConcept C86803240 @default.
• W2938371473 hasConceptScore W2938371473C121608353 @default.
• W2938371473 hasConceptScore W2938371473C126322002 @default.
• W2938371473 hasConceptScore W2938371473C142724271 @default.
• W2938371473 hasConceptScore W2938371473C159654299 @default.
• W2938371473 hasConceptScore W2938371473C203014093 @default.
• W2938371473 hasConceptScore W2938371473C204232928 @default.
• W2938371473 hasConceptScore W2938371473C2777714996 @default.
• W2938371473 hasConceptScore W2938371473C2781182431 @default.
• W2938371473 hasConceptScore W2938371473C502942594 @default.
• W2938371473 hasConceptScore W2938371473C71924100 @default.
• W2938371473 hasConceptScore W2938371473C86803240 @default.
• W2938371473 hasIssue "4" @default.
• W2938371473 hasLocation W29383714731 @default.
• W2938371473 hasLocation W29383714732 @default.
• W2938371473 hasLocation W29383714733 @default.
• W2938371473 hasLocation W29383714734 @default.
• W2938371473 hasLocation W29383714735 @default.
• W2938371473 hasOpenAccess W2938371473 @default.
• W2938371473 hasPrimaryLocation W29383714731 @default.
• W2938371473 hasRelatedWork W1969927172 @default.
• W2938371473 hasRelatedWork W2009547022 @default.
• W2938371473 hasRelatedWork W2109373031 @default.
• W2938371473 hasRelatedWork W2363326412 @default.
• W2938371473 hasRelatedWork W2364973444 @default.
• W2938371473 hasRelatedWork W2381641909 @default.
• W2938371473 hasRelatedWork W2411770056 @default.
• W2938371473 hasRelatedWork W2438622766 @default.
• W2938371473 hasRelatedWork W2947306981 @default.
• W2938371473 hasRelatedWork W33978073 @default.
• W2938371473 hasVolume "14" @default.

• next