Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938372383> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2938372383 endingPage "143" @default.
- W2938372383 startingPage "141" @default.
- W2938372383 abstract "NeuroscienceA better understanding of the mechanisms underlying the action of antidepressants is urgently needed. Moda-Sava et al. explored a possible mode of action for the drug ketamine, which has recently been shown to help patients recover from depression (see the Perspective by Beyeler). Ketamine rescued behavior in mice that was associated with depression-like phenotypes by selectively reversing stress-induced spine loss and restoring coordinated multicellular ensemble activity in prefrontal microcircuits. The initial induction of ketamine's antidepressant effect on mouse behavior occurred independently of effects on spine formation. Instead, synaptogenesis in the prefrontal region played a critical role in nourishing these effects over time. Interventions aimed at enhancing the survival of restored synapses may thus be useful for sustaining the behavioral effects of fast-acting antidepressants.Science , this issue p. [eaat8078][1]; see also p. [129][2] [1]: /lookup/doi/10.1126/science.aat8078 [2]: /lookup/doi/10.1126/science.aax0719" @default.
- W2938372383 created "2019-04-25" @default.
- W2938372383 creator A5026955262 @default.
- W2938372383 date "2019-04-12" @default.
- W2938372383 modified "2023-09-24" @default.
- W2938372383 title "Why is ketamine an antidepressant" @default.
- W2938372383 doi "https://doi.org/10.1126/science.364.6436.141-m" @default.
- W2938372383 hasPublicationYear "2019" @default.
- W2938372383 type Work @default.
- W2938372383 sameAs 2938372383 @default.
- W2938372383 citedByCount "0" @default.
- W2938372383 crossrefType "journal-article" @default.
- W2938372383 hasAuthorship W2938372383A5026955262 @default.
- W2938372383 hasConcept C139719470 @default.
- W2938372383 hasConcept C15744967 @default.
- W2938372383 hasConcept C162324750 @default.
- W2938372383 hasConcept C169760540 @default.
- W2938372383 hasConcept C2776867660 @default.
- W2938372383 hasConcept C2779177272 @default.
- W2938372383 hasConcept C2780795376 @default.
- W2938372383 hasConcept C2781161787 @default.
- W2938372383 hasConcept C65232495 @default.
- W2938372383 hasConceptScore W2938372383C139719470 @default.
- W2938372383 hasConceptScore W2938372383C15744967 @default.
- W2938372383 hasConceptScore W2938372383C162324750 @default.
- W2938372383 hasConceptScore W2938372383C169760540 @default.
- W2938372383 hasConceptScore W2938372383C2776867660 @default.
- W2938372383 hasConceptScore W2938372383C2779177272 @default.
- W2938372383 hasConceptScore W2938372383C2780795376 @default.
- W2938372383 hasConceptScore W2938372383C2781161787 @default.
- W2938372383 hasConceptScore W2938372383C65232495 @default.
- W2938372383 hasIssue "6436" @default.
- W2938372383 hasLocation W29383723831 @default.
- W2938372383 hasOpenAccess W2938372383 @default.
- W2938372383 hasPrimaryLocation W29383723831 @default.
- W2938372383 hasRelatedWork W2002843427 @default.
- W2938372383 hasRelatedWork W2124203952 @default.
- W2938372383 hasRelatedWork W2156342513 @default.
- W2938372383 hasRelatedWork W2335670754 @default.
- W2938372383 hasRelatedWork W2372948087 @default.
- W2938372383 hasRelatedWork W2416159552 @default.
- W2938372383 hasRelatedWork W2546531144 @default.
- W2938372383 hasRelatedWork W2559481138 @default.
- W2938372383 hasRelatedWork W2768783254 @default.
- W2938372383 hasRelatedWork W2775504840 @default.
- W2938372383 hasRelatedWork W2916488473 @default.
- W2938372383 hasRelatedWork W2954699289 @default.
- W2938372383 hasRelatedWork W2996052033 @default.
- W2938372383 hasRelatedWork W3000480376 @default.
- W2938372383 hasRelatedWork W3004131643 @default.
- W2938372383 hasRelatedWork W3016139448 @default.
- W2938372383 hasRelatedWork W3031694945 @default.
- W2938372383 hasRelatedWork W3108229983 @default.
- W2938372383 hasRelatedWork W3174949733 @default.
- W2938372383 hasRelatedWork W3197016915 @default.
- W2938372383 hasVolume "364" @default.
- W2938372383 isParatext "false" @default.
- W2938372383 isRetracted "false" @default.
- W2938372383 magId "2938372383" @default.
- W2938372383 workType "article" @default.