FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938387685> ?p ?o ?g. }

• W2938387685 endingPage "20" @default.
• W2938387685 startingPage "8" @default.
• W2938387685 abstract "Metal ions or nanoparticles are believed to be promising additives in developing antibacterial biomaterials, owing to possessing favorable bactericidal effects against antibiotic-resistant bacteria. However, the immunomodulatory antibacterial activity of metal ions has seldom been reported. Herein, a porous microstructure designed to trap methicillin-resistant Staphylococcus aureus (MRSA) is fabricated on polyetheretherketone biomaterial surface through sulfonation (SPEEK), following which copper (Cu) nanoparticles, which can kill the trapped MRSA, are immobilized on SPEEK surface using a customized magnetron sputtering technique. In vitro antibacterial and immunological experiments indicate that the Cu-incorporated SPEEK can exert a desirable bactericidal effect against MRSA through the combination of “trap killing” and “contact killing” actions; meanwhile, macrophages cultured on the Cu-incorporated SPEEK can be activated and polarized to a pro-inflammatory phenotype along with improved phagocytic ability on the MRSA. Further in vivo implant-associated infection models evidence the superior antibacterial activity of the Cu-incorporated SPEEK. These results demonstrate multimodal antibacterial actions of the Cu-incorporated SPEEK, which is capable of imposing direct antibacterial and indirect immunomodulatory antibacterial effects simultaneously, in order to prevent and cure MRSA infection. It is believed that this study may shed light on developing novel biomaterial implants that combine antibacterial and immunomodulatory functions." @default.
• W2938387685 created "2019-04-25" @default.
• W2938387685 creator A5001097658 @default.
• W2938387685 creator A5003829833 @default.
• W2938387685 creator A5019080790 @default.
• W2938387685 creator A5026185932 @default.
• W2938387685 creator A5040910724 @default.
• W2938387685 creator A5071037763 @default.
• W2938387685 creator A5082656873 @default.
• W2938387685 creator A5084893043 @default.
• W2938387685 date "2019-07-01" @default.
• W2938387685 modified "2023-10-18" @default.
• W2938387685 title "A surface-engineered polyetheretherketone biomaterial implant with direct and immunoregulatory antibacterial activity against methicillin-resistant Staphylococcus aureus" @default.
• W2938387685 cites W1536916194 @default.
• W2938387685 cites W1582288352 @default.
• W2938387685 cites W1830530885 @default.
• W2938387685 cites W1907075739 @default.
• W2938387685 cites W1963975473 @default.
• W2938387685 cites W1977162717 @default.
• W2938387685 cites W1983255179 @default.
• W2938387685 cites W1987154750 @default.
• W2938387685 cites W2000449686 @default.
• W2938387685 cites W2000958961 @default.
• W2938387685 cites W2002025851 @default.
• W2938387685 cites W2012196995 @default.
• W2938387685 cites W2015796932 @default.
• W2938387685 cites W2017052168 @default.
• W2938387685 cites W2026205946 @default.
• W2938387685 cites W2034351768 @default.
• W2938387685 cites W2034634701 @default.
• W2938387685 cites W2038846800 @default.
• W2938387685 cites W2067234598 @default.
• W2938387685 cites W2072241841 @default.
• W2938387685 cites W2072429116 @default.
• W2938387685 cites W2072884589 @default.
• W2938387685 cites W2078451920 @default.
• W2938387685 cites W2086758442 @default.
• W2938387685 cites W2099771055 @default.
• W2938387685 cites W2108152814 @default.
• W2938387685 cites W2109872165 @default.
• W2938387685 cites W2110871531 @default.
• W2938387685 cites W2113888101 @default.
• W2938387685 cites W2114908128 @default.
• W2938387685 cites W2121367167 @default.
• W2938387685 cites W2124353241 @default.
• W2938387685 cites W2131727615 @default.
• W2938387685 cites W2134118368 @default.
• W2938387685 cites W2139724705 @default.
• W2938387685 cites W2157177676 @default.
• W2938387685 cites W2207576671 @default.
• W2938387685 cites W2214330682 @default.
• W2938387685 cites W2221356237 @default.
• W2938387685 cites W2230074349 @default.
• W2938387685 cites W2232019269 @default.
• W2938387685 cites W2237653881 @default.
• W2938387685 cites W2337242479 @default.
• W2938387685 cites W2381150084 @default.
• W2938387685 cites W2493697912 @default.
• W2938387685 cites W2510118916 @default.
• W2938387685 cites W2513925640 @default.
• W2938387685 cites W2549697151 @default.
• W2938387685 cites W2620160911 @default.
• W2938387685 cites W2766444361 @default.
• W2938387685 cites W2789641767 @default.
• W2938387685 cites W2792029853 @default.
• W2938387685 cites W2792888809 @default.
• W2938387685 cites W2801023552 @default.
• W2938387685 cites W2802064771 @default.
• W2938387685 cites W2804696000 @default.
• W2938387685 cites W2807259255 @default.
• W2938387685 cites W2809266196 @default.
• W2938387685 cites W2913777404 @default.
• W2938387685 cites W4211196871 @default.
• W2938387685 doi "https://doi.org/10.1016/j.biomaterials.2019.04.008" @default.
• W2938387685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30986611" @default.
• W2938387685 hasPublicationYear "2019" @default.
• W2938387685 type Work @default.
• W2938387685 sameAs 2938387685 @default.
• W2938387685 citedByCount "109" @default.
• W2938387685 countsByYear W29383876852019 @default.
• W2938387685 countsByYear W29383876852020 @default.
• W2938387685 countsByYear W29383876852021 @default.
• W2938387685 countsByYear W29383876852022 @default.
• W2938387685 countsByYear W29383876852023 @default.
• W2938387685 crossrefType "journal-article" @default.
• W2938387685 hasAuthorship W2938387685A5001097658 @default.
• W2938387685 hasAuthorship W2938387685A5003829833 @default.
• W2938387685 hasAuthorship W2938387685A5019080790 @default.
• W2938387685 hasAuthorship W2938387685A5026185932 @default.
• W2938387685 hasAuthorship W2938387685A5040910724 @default.
• W2938387685 hasAuthorship W2938387685A5071037763 @default.
• W2938387685 hasAuthorship W2938387685A5082656873 @default.
• W2938387685 hasAuthorship W2938387685A5084893043 @default.
• W2938387685 hasConcept C115537861 @default.
• W2938387685 hasConcept C147789679 @default.
• W2938387685 hasConcept C150903083 @default.
• W2938387685 hasConcept C155672457 @default.
• W2938387685 hasConcept C171250308 @default.

• next