Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938408743> ?p ?o ?g. }
- W2938408743 abstract "Infection with IAVs leads to the induction of complex signaling cascades, which apparently serve two opposing functions. On the one hand, the virus highjacks cellular signaling cascades in order to support its propagation; on the other hand, the host cell triggers antiviral signaling networks. Here we focused on IAV-triggered phosphorylation events in a systematic fashion by deep sequencing of the phosphoproteomes. This study revealed a plethora of newly phosphorylated proteins. We also identified 37 protein kinases and a range of phosphatases that are activated or inactivated following IAV infection. Moreover, we identified new phosphorylation sites on IAV-encoded proteins. Some of these phosphorylations support the enzymatic function of viral components, while other phosphorylations are inhibitory, as exemplified by PB1 Thr223 modification. Our global characterization of IAV-triggered patterns of phospho-proteins provides a rich resource to further understand host responses to infection at the level of phosphorylation-dependent signaling networks." @default.
- W2938408743 created "2019-04-25" @default.
- W2938408743 creator A5011993421 @default.
- W2938408743 creator A5019383564 @default.
- W2938408743 creator A5019631070 @default.
- W2938408743 creator A5038809023 @default.
- W2938408743 creator A5040887859 @default.
- W2938408743 creator A5042016744 @default.
- W2938408743 creator A5056324322 @default.
- W2938408743 creator A5069332888 @default.
- W2938408743 creator A5078288449 @default.
- W2938408743 creator A5080372373 @default.
- W2938408743 creator A5086007862 @default.
- W2938408743 creator A5087300609 @default.
- W2938408743 creator A5091239733 @default.
- W2938408743 date "2019-07-01" @default.
- W2938408743 modified "2023-10-12" @default.
- W2938408743 title "Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks" @default.
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