FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938421792> ?p ?o ?g. }

• W2938421792 endingPage "2618" @default.
• W2938421792 startingPage "2609" @default.
• W2938421792 abstract "EGFP-EGF1-conjugated poly(lactic-co-glycolic acid) (PLGA) nanoparticle (ENP) has a specific affinity to tissue factor (TF). The aim of this study was to investigate the target delivery of ENP to plaques and its uptake in a mouse model of atherosclerosis in vivo and in vitro.Coumarin-6- and 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbo cyanine iodide (DiR)-loaded ENPs were synthesized using a double-emulsion method. Mouse vascular smooth muscle cells (VSMCs) were induced with MCP-1 to obtain an increased TF expression. Fluorescence microscopy and flow cytometry assay were performed to examine the uptake of coumarin-6-loaded ENPs in cellular models. An animal model of atherosclerosis was established with an ApoE (-/-) mouse fed with continuous high-fat diets for 14 weeks. DiR-loaded ENPs (DiR-ENPs) were injected via the caudal vein. The distribution of DiR-ENPs was examined through organ imaging and confocal laser scanning microscopy.Results indicated TFs were highly expressed in the cellular model. The uptake of coumarin-6-loaded ENPs was significantly higher than that of common PLGA nanoparticles. Thickening of intima and lipid deposition in the aorta could be observed in atherosclerosis mouse models. Confocal laser scanning microscopy organ imaging showed ENPs accumulated in vessels with atherosclerotic plaques, which coincided with high expressions of TF.This study showed that EGFP-EGF1-conjugated PLGA nanoparticles could be effectively delivered to atherosclerotic plaques in vivo and taken up by VSMCs with high TF expressions in vitro. Thus, it could be a promising carrier for targeted therapy of atherosclerosis." @default.
• W2938421792 created "2019-04-25" @default.
• W2938421792 creator A5011877804 @default.
• W2938421792 creator A5019657883 @default.
• W2938421792 creator A5026192010 @default.
• W2938421792 creator A5034753161 @default.
• W2938421792 creator A5063253432 @default.
• W2938421792 creator A5070726877 @default.
• W2938421792 creator A5080853070 @default.
• W2938421792 creator A5084866770 @default.
• W2938421792 creator A5090366405 @default.
• W2938421792 date "2019-04-01" @default.
• W2938421792 modified "2023-09-25" @default.
• W2938421792 title "<p>EGFP-EGF1-conjugated poly(lactic-co-glycolic acid) nanoparticles, a new diagnostic tool and drug carrier for atherosclerosis</p>" @default.
• W2938421792 cites W1129572659 @default.
• W2938421792 cites W1941499335 @default.
• W2938421792 cites W1964064254 @default.
• W2938421792 cites W1964440464 @default.
• W2938421792 cites W1967810569 @default.
• W2938421792 cites W1970015059 @default.
• W2938421792 cites W1970183428 @default.
• W2938421792 cites W1978040433 @default.
• W2938421792 cites W1998182735 @default.
• W2938421792 cites W2005382591 @default.
• W2938421792 cites W2015490918 @default.
• W2938421792 cites W2020245957 @default.
• W2938421792 cites W2020398834 @default.
• W2938421792 cites W2033896075 @default.
• W2938421792 cites W2037981489 @default.
• W2938421792 cites W2045274918 @default.
• W2938421792 cites W2054506834 @default.
• W2938421792 cites W2061921068 @default.
• W2938421792 cites W2064255959 @default.
• W2938421792 cites W2065624229 @default.
• W2938421792 cites W2066963386 @default.
• W2938421792 cites W2069709543 @default.
• W2938421792 cites W2075099351 @default.
• W2938421792 cites W2077660349 @default.
• W2938421792 cites W2078018645 @default.
• W2938421792 cites W2079724669 @default.
• W2938421792 cites W2093203595 @default.
• W2938421792 cites W2094629035 @default.
• W2938421792 cites W2098486305 @default.
• W2938421792 cites W2103839593 @default.
• W2938421792 cites W2111216870 @default.
• W2938421792 cites W2146933358 @default.
• W2938421792 cites W2156593520 @default.
• W2938421792 cites W2163033675 @default.
• W2938421792 cites W2168414839 @default.
• W2938421792 cites W2169083127 @default.
• W2938421792 cites W2238180128 @default.
• W2938421792 cites W2411166269 @default.
• W2938421792 cites W2810532646 @default.
• W2938421792 cites W54801374 @default.
• W2938421792 doi "https://doi.org/10.2147/ijn.s199695" @default.
• W2938421792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6469482" @default.
• W2938421792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31043777" @default.
• W2938421792 hasPublicationYear "2019" @default.
• W2938421792 type Work @default.
• W2938421792 sameAs 2938421792 @default.
• W2938421792 citedByCount "6" @default.
• W2938421792 countsByYear W29384217922020 @default.
• W2938421792 countsByYear W29384217922021 @default.
• W2938421792 countsByYear W29384217922022 @default.
• W2938421792 countsByYear W29384217922023 @default.
• W2938421792 crossrefType "journal-article" @default.
• W2938421792 hasAuthorship W2938421792A5011877804 @default.
• W2938421792 hasAuthorship W2938421792A5019657883 @default.
• W2938421792 hasAuthorship W2938421792A5026192010 @default.
• W2938421792 hasAuthorship W2938421792A5034753161 @default.
• W2938421792 hasAuthorship W2938421792A5063253432 @default.
• W2938421792 hasAuthorship W2938421792A5070726877 @default.
• W2938421792 hasAuthorship W2938421792A5080853070 @default.
• W2938421792 hasAuthorship W2938421792A5084866770 @default.
• W2938421792 hasAuthorship W2938421792A5090366405 @default.
• W2938421792 hasBestOaLocation W29384217921 @default.
• W2938421792 hasConcept C121332964 @default.
• W2938421792 hasConcept C12554922 @default.
• W2938421792 hasConcept C150903083 @default.
• W2938421792 hasConcept C153911025 @default.
• W2938421792 hasConcept C169274487 @default.
• W2938421792 hasConcept C185592680 @default.
• W2938421792 hasConcept C192562407 @default.
• W2938421792 hasConcept C202751555 @default.
• W2938421792 hasConcept C207001950 @default.
• W2938421792 hasConcept C26291073 @default.
• W2938421792 hasConcept C2779178360 @default.
• W2938421792 hasConcept C2780165375 @default.
• W2938421792 hasConcept C553184892 @default.
• W2938421792 hasConcept C55493867 @default.
• W2938421792 hasConcept C62520636 @default.
• W2938421792 hasConcept C86803240 @default.
• W2938421792 hasConcept C91881484 @default.
• W2938421792 hasConcept C95444343 @default.
• W2938421792 hasConceptScore W2938421792C121332964 @default.
• W2938421792 hasConceptScore W2938421792C12554922 @default.
• W2938421792 hasConceptScore W2938421792C150903083 @default.
• W2938421792 hasConceptScore W2938421792C153911025 @default.

• next