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- W2938434650 abstract "Background . Hypertension (HPT) is often underdiagnosed in children, although significant morbidity and mortality arises from hypertensive target organ damage and hypertensive crises. Objectives . To determine the prevalence, complications and causes of severe HPT in children 12 years old at a central hospital. Methods . Hospital records of children 12 years old with severe HPT (stage 2 and higher) from 2005 to 2014 were reviewed. Demographics, nutritional status, causes, HIV status, presence of target organ damage and treatment were analysed. Results . Of 821 children admitted to the paediatric nephrology unit, 152 (18.5%) children had severe HPT, with a mean age of 6.3 years; 86 (57%) were boys. A total of 28 (19%) were HIV-positive, and 19 (68%) were treatment naive. Kidney disease accounted for 82% of cases, 46 (30%) having steroid-resistant nephrotic syndrome, 22 (14%) HIV-associated nephropathy, 19 (13%) glomerulonephritis, 21 (14%) congenital urinary tract abnormalities and 17 (11%) other renal causes. Renovascular causes accounted for 12 (8%) cases. Of these 12, 7 (58%) had left ventricular hypertrophy (LVH), compared with 10/125 (8%) who had other forms of kidney disease ( p <0.023). Hypertensive crises occurred in 28 (18%) patients, and were significantly more common in children with HPT secondary to renovascular causes than renal causes ( p =0.001). Conclusion. Renal diseases were the most common cause of severe HPT in children. Hypertensive crises, retinopathy and LVH are common in renovascular HPT." @default.
- W2938434650 created "2019-04-25" @default.
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- W2938434650 date "2019-04-11" @default.
- W2938434650 modified "2023-09-25" @default.
- W2938434650 title "Severe hypertension in children at a central referral hospital in KwaZulu-Natal Province, South Africa" @default.
- W2938434650 doi "https://doi.org/10.7196/sajch.2019.v13i1.1564" @default.
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