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• W2938447325 abstract "Motor Neuron Disease (MND) typically affects patients during the later stages of life, and thus, MND is having an increasingly devastating impact on diagnosed individuals, their families and society. The umbrella term MND refers to diseases which cause the progressive loss of upper and/or lower motor neurons and a subsequent decrease in motor ability such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). The study of these diseases is complex and has recently involved the use of genome-wide association studies (GWAS). However, in the case of MND, it has been difficult to identify the complex genetics involved in subtypes, and functional investigation of new candidate disease genes is warranted. Drosophila is a powerful model for addressing these complex diseases. The UAS/Gal4/Gal80 system allows for the upregulation of Drosophila genes, the knockdown of genes and the ectopic expression of human genes or mutations in a tissue-specific manner; often resulting in Drosophila models which exhibit typical MND disease pathologies. These can then be further interrogated to identify disease-modifying genes or mutations and disease pathways. This review will discuss two common MNDs and the current Drosophila models which are being used to research their genetic basis and the different pathologies of MND." @default.
• W2938447325 created "2019-04-25" @default.
• W2938447325 creator A5011997834 @default.
• W2938447325 creator A5019567565 @default.
• W2938447325 creator A5057582207 @default.
• W2938447325 date "2019-04-12" @default.
• W2938447325 modified "2023-09-30" @default.
• W2938447325 title "Dissecting Motor Neuron Disease With Drosophila melanogaster" @default.
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