FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938474947> ?p ?o ?g. }

• W2938474947 endingPage "23" @default.
• W2938474947 startingPage "16" @default.
• W2938474947 abstract "One of the hallmark events during liver fibrosis is the transition of quiescent hepatic stellate cells (HSC) into activated myofibroblasts, which are responsible for the production and deposition of pro-fibrogenic proteins. The epigenetic mechanism underlying HSC trans-differentiation is not fully understood. In the present study we investigated the contribution of histone H3K9 demethylase KDM4 in this process. We report that expression levels of KDM4 were down-regulated during HSC activation paralleling the up-regulation of alpha smooth muscle cell actin (Acta2), a marker of mature myofibroblast. Furthermore, HSCs isolated from mice induced to develop liver fibrosis exhibit lowered KDM4 expression compared to the control mice. In accordance, KDM4 depletion with siRNA accelerated HSC activation. Of interest, the loss of KDM4 was mirrored by the repression of miR-29, an antagonist of liver fibrosis, during HSC activation both in vitro and in vivo. KDM4 knockdown resulted in the down-regulation of miR-29 expression. Mechanistically, the sequence-specific transcription factor SREBP2 interacted with KDM4 to activate miR-29 transcription. In conclusion, our data delineate a novel epigenetic mechanism underlying HSC activation. Targeting this axis may yield potential therapeutics against liver fibrosis." @default.
• W2938474947 created "2019-04-25" @default.
• W2938474947 creator A5009664545 @default.
• W2938474947 creator A5019685555 @default.
• W2938474947 creator A5043078772 @default.
• W2938474947 creator A5049743689 @default.
• W2938474947 creator A5061115188 @default.
• W2938474947 creator A5067483347 @default.
• W2938474947 date "2019-06-01" @default.
• W2938474947 modified "2023-10-18" @default.
• W2938474947 title "The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription" @default.
• W2938474947 cites W1012116906 @default.
• W2938474947 cites W1517919299 @default.
• W2938474947 cites W1831059025 @default.
• W2938474947 cites W1831392484 @default.
• W2938474947 cites W1995595077 @default.
• W2938474947 cites W2006318229 @default.
• W2938474947 cites W2009036920 @default.
• W2938474947 cites W2011646758 @default.
• W2938474947 cites W2039776909 @default.
• W2938474947 cites W2057095258 @default.
• W2938474947 cites W2064595979 @default.
• W2938474947 cites W2067845573 @default.
• W2938474947 cites W2093281361 @default.
• W2938474947 cites W2099486691 @default.
• W2938474947 cites W2103996457 @default.
• W2938474947 cites W2107735993 @default.
• W2938474947 cites W2109697658 @default.
• W2938474947 cites W2122889756 @default.
• W2938474947 cites W2142983739 @default.
• W2938474947 cites W2143658931 @default.
• W2938474947 cites W2150609732 @default.
• W2938474947 cites W2230411827 @default.
• W2938474947 cites W2270555377 @default.
• W2938474947 cites W2498539528 @default.
• W2938474947 cites W2533354568 @default.
• W2938474947 cites W2591743962 @default.
• W2938474947 cites W2617376742 @default.
• W2938474947 cites W2745765928 @default.
• W2938474947 cites W2755414398 @default.
• W2938474947 cites W2762080276 @default.
• W2938474947 cites W2767137153 @default.
• W2938474947 cites W2806816753 @default.
• W2938474947 cites W2809163765 @default.
• W2938474947 cites W2865334598 @default.
• W2938474947 cites W2883824376 @default.
• W2938474947 cites W2883954573 @default.
• W2938474947 cites W2885739392 @default.
• W2938474947 cites W2887593965 @default.
• W2938474947 cites W2888545755 @default.
• W2938474947 doi "https://doi.org/10.1016/j.bbrc.2019.04.105" @default.
• W2938474947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31014673" @default.
• W2938474947 hasPublicationYear "2019" @default.
• W2938474947 type Work @default.
• W2938474947 sameAs 2938474947 @default.
• W2938474947 citedByCount "7" @default.
• W2938474947 countsByYear W29384749472020 @default.
• W2938474947 countsByYear W29384749472021 @default.
• W2938474947 countsByYear W29384749472022 @default.
• W2938474947 countsByYear W29384749472023 @default.
• W2938474947 crossrefType "journal-article" @default.
• W2938474947 hasAuthorship W2938474947A5009664545 @default.
• W2938474947 hasAuthorship W2938474947A5019685555 @default.
• W2938474947 hasAuthorship W2938474947A5043078772 @default.
• W2938474947 hasAuthorship W2938474947A5049743689 @default.
• W2938474947 hasAuthorship W2938474947A5061115188 @default.
• W2938474947 hasAuthorship W2938474947A5067483347 @default.
• W2938474947 hasConcept C104317684 @default.
• W2938474947 hasConcept C126322002 @default.
• W2938474947 hasConcept C134018914 @default.
• W2938474947 hasConcept C138885662 @default.
• W2938474947 hasConcept C173396325 @default.
• W2938474947 hasConcept C176891718 @default.
• W2938474947 hasConcept C179926584 @default.
• W2938474947 hasConcept C185592680 @default.
• W2938474947 hasConcept C207865475 @default.
• W2938474947 hasConcept C2780559512 @default.
• W2938474947 hasConcept C2781364455 @default.
• W2938474947 hasConcept C41091548 @default.
• W2938474947 hasConcept C41895202 @default.
• W2938474947 hasConcept C502942594 @default.
• W2938474947 hasConcept C54355233 @default.
• W2938474947 hasConcept C55493867 @default.
• W2938474947 hasConcept C64927066 @default.
• W2938474947 hasConcept C71924100 @default.
• W2938474947 hasConcept C81885089 @default.
• W2938474947 hasConcept C86339819 @default.
• W2938474947 hasConcept C86803240 @default.
• W2938474947 hasConcept C95444343 @default.
• W2938474947 hasConceptScore W2938474947C104317684 @default.
• W2938474947 hasConceptScore W2938474947C126322002 @default.
• W2938474947 hasConceptScore W2938474947C134018914 @default.
• W2938474947 hasConceptScore W2938474947C138885662 @default.
• W2938474947 hasConceptScore W2938474947C173396325 @default.
• W2938474947 hasConceptScore W2938474947C176891718 @default.
• W2938474947 hasConceptScore W2938474947C179926584 @default.
• W2938474947 hasConceptScore W2938474947C185592680 @default.
• W2938474947 hasConceptScore W2938474947C207865475 @default.

• next