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• W2938494993 endingPage "502" @default.
• W2938494993 startingPage "493" @default.
• W2938494993 abstract "HtrA and HtrB are two important proteases across species. In biotechnological industries, they are related to degradation of secreted heterologous proteins from bacteria, especially in the case of overproduction of α-amylases in Bacillus subtilis. Induction of HtrA and HtrB synthesis follows the overproduction of α-amylases in B. subtilis. This is different from the order usually observed in B. subtilis, i.e., the production of proteases is prior to the secretion of proteins. This discrepancy suggests three possibilities: (i) HtrA and HtrB are constantly synthesized from the end of the exponential phase, and then are synthesized more abundantly due to secretion stress; (ii) There is a hysteresis mechanism that holds HtrA and HtrB back from their large amount of secretion before the overproduction of α-amylases; (iii) Heterologous amylases could be a stress to B. subtilis leading to a general response to stress. In this review, we analyze the literature to explore these three possibilities. The first possibility is attributed to the regulatory pathway of CssR-CssS. The second possibility is because sigma factor σD plays a role in the overproduction of α-amylases and is subpopulation dependent with the switch between ON and OFF states that is fundamental for a bistable system and a hysteresis mechanism. Thus, sigma factor σD helps to hold HtrA and HtrB back from massive secretion before the overproduction of α-amylases. The third possibility is that several sigma factors promote the secretion of proteases at the end of the exponential phase of growth under the condition that heterologous amylases are considered as a stress." @default.
• W2938494993 created "2019-04-25" @default.
• W2938494993 creator A5034316640 @default.
• W2938494993 creator A5044041420 @default.
• W2938494993 date "2019-04-18" @default.
• W2938494993 modified "2023-10-17" @default.
• W2938494993 title "Proteases HtrA and HtrB for α-amylase secreted from Bacillus subtilis in secretion stress" @default.
• W2938494993 cites W1497811962 @default.
• W2938494993 cites W1521877748 @default.
• W2938494993 cites W1537135914 @default.
• W2938494993 cites W1549831375 @default.
• W2938494993 cites W1558931515 @default.
• W2938494993 cites W1581673713 @default.
• W2938494993 cites W1607384859 @default.
• W2938494993 cites W1757147742 @default.
• W2938494993 cites W1835434814 @default.
• W2938494993 cites W1856112995 @default.
• W2938494993 cites W1900856863 @default.
• W2938494993 cites W1912762643 @default.
• W2938494993 cites W1966672397 @default.
• W2938494993 cites W1972222322 @default.
• W2938494993 cites W1972509620 @default.
• W2938494993 cites W1974000166 @default.
• W2938494993 cites W1975635548 @default.
• W2938494993 cites W1990659194 @default.
• W2938494993 cites W2000967117 @default.
• W2938494993 cites W2005624288 @default.
• W2938494993 cites W2012547722 @default.
• W2938494993 cites W2012757590 @default.
• W2938494993 cites W2021606207 @default.
• W2938494993 cites W2023131321 @default.
• W2938494993 cites W2026169768 @default.
• W2938494993 cites W2026228757 @default.
• W2938494993 cites W2029268098 @default.
• W2938494993 cites W2029920657 @default.
• W2938494993 cites W2030285233 @default.
• W2938494993 cites W2044522314 @default.
• W2938494993 cites W2047930189 @default.
• W2938494993 cites W2053149333 @default.
• W2938494993 cites W2055872227 @default.
• W2938494993 cites W2058243732 @default.
• W2938494993 cites W2060198449 @default.
• W2938494993 cites W2060470131 @default.
• W2938494993 cites W2064305061 @default.
• W2938494993 cites W2065360727 @default.
• W2938494993 cites W2069055532 @default.
• W2938494993 cites W2081373054 @default.
• W2938494993 cites W2082211585 @default.
• W2938494993 cites W2087494997 @default.
• W2938494993 cites W2096209101 @default.
• W2938494993 cites W2098883789 @default.
• W2938494993 cites W2100521476 @default.
• W2938494993 cites W2100975834 @default.
• W2938494993 cites W2101095848 @default.
• W2938494993 cites W2101372972 @default.
• W2938494993 cites W2103570403 @default.
• W2938494993 cites W2105291560 @default.
• W2938494993 cites W2106744027 @default.
• W2938494993 cites W2107824577 @default.
• W2938494993 cites W2108424129 @default.
• W2938494993 cites W2111086397 @default.
• W2938494993 cites W2111712628 @default.
• W2938494993 cites W2119045079 @default.
• W2938494993 cites W2119635786 @default.
• W2938494993 cites W2120242788 @default.
• W2938494993 cites W2120590644 @default.
• W2938494993 cites W2122558314 @default.
• W2938494993 cites W2123720278 @default.
• W2938494993 cites W2125857607 @default.
• W2938494993 cites W2127597865 @default.
• W2938494993 cites W2133397415 @default.
• W2938494993 cites W2134262076 @default.
• W2938494993 cites W2138170124 @default.
• W2938494993 cites W2143709701 @default.
• W2938494993 cites W2146156845 @default.
• W2938494993 cites W2147057508 @default.
• W2938494993 cites W2148707930 @default.
• W2938494993 cites W2152025039 @default.
• W2938494993 cites W2154661457 @default.
• W2938494993 cites W2156133364 @default.
• W2938494993 cites W2156860336 @default.
• W2938494993 cites W2157557763 @default.
• W2938494993 cites W2157974567 @default.
• W2938494993 cites W2159457776 @default.
• W2938494993 cites W2160987816 @default.
• W2938494993 cites W2162123959 @default.
• W2938494993 cites W2162528201 @default.
• W2938494993 cites W2162959566 @default.
• W2938494993 cites W2163288778 @default.
• W2938494993 cites W2163928879 @default.
• W2938494993 cites W2167474125 @default.
• W2938494993 cites W2172287485 @default.
• W2938494993 cites W2227246412 @default.
• W2938494993 cites W2275528045 @default.
• W2938494993 cites W2314515104 @default.
• W2938494993 cites W2528713039 @default.
• W2938494993 cites W2566075162 @default.
• W2938494993 cites W2738158054 @default.

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