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• W2938507534 abstract "The nearly neutral theory of molecular evolution predicts that the efficacy of natural selection increases with the effective population size. This prediction has been verified by independent observations in diverse taxa, which show that life-history traits are strongly correlated with measures of the efficacy of selection, such as the dN/dS ratio. Surprisingly, avian taxa are an exception to this theory because correlations between life-history traits and dN/dS are apparently absent. Here we explore the role of GC-biased gene conversion on estimates of substitution rates as a potential driver of these unexpected observations. We analyze the relationship between dN/dS estimated from alignments of 47 avian genomes and several proxies for effective population size. To distinguish the impact of GC-biased gene conversion from selection, we use an approach that accounts for non-stationary base composition and estimate dN/dS separately for changes affected or unaffected by GC-biased gene conversion. This analysis shows that the impact of GC-biased gene conversion on substitution rates can explain the lack of correlations between life-history traits and dN/dS. Strong correlations between life-history traits and dN/dS are recovered after accounting for GC-biased gene conversion. The correlations are robust to variation in base composition and genomic location. Our study shows that gene sequence evolution across a wide range of avian lineages meets the prediction of the nearly neutral theory, the efficacy of selection increases with effective population size. Moreover, our study illustrates that accounting for GC-biased gene conversion is important to correctly estimate the strength of selection." @default.
• W2938507534 created "2019-04-25" @default.
• W2938507534 creator A5036099891 @default.
• W2938507534 creator A5060523727 @default.
• W2938507534 creator A5067111948 @default.
• W2938507534 creator A5073922372 @default.
• W2938507534 creator A5079476145 @default.
• W2938507534 date "2019-01-07" @default.
• W2938507534 modified "2023-10-16" @default.
• W2938507534 title "GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes" @default.
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• W2938507534 doi "https://doi.org/10.1186/s13059-018-1613-z" @default.
• W2938507534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6322265" @default.
• W2938507534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30616647" @default.
• W2938507534 hasPublicationYear "2019" @default.
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