Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938508587> ?p ?o ?g. }
- W2938508587 endingPage "111921" @default.
- W2938508587 startingPage "111921" @default.
- W2938508587 abstract "Neonatal brain injury from hypoxia-ischemia (HI) causes major morbidity. Piglet HI is an established method for testing neuroprotective treatments in large, gyrencephalic brain. Though many neurobehavior tests exist for rodents, such tests and their associations with neuropathologic injury remain underdeveloped and underutilized in large, neonatal HI animal models. We examined whether spatial T-maze and inclined beam tests distinguish cognitive and motor differences between HI and sham piglets and correlate with neuropathologic injury. Neonatal piglets were randomized to whole-body HI or sham procedure, and they began T-maze and inclined beam testing 17 days later. HI piglets had more incorrect T-maze turns than did shams. Beam walking time did not differ between groups. Neuropathologic evaluations at 33 days validated the injury with putamen neuron loss after HI to below that of sham procedure. HI decreased the numbers of CA3 pyramidal neurons but not CA1 pyramidal neurons or dentate gyrus granule neurons. Though the number of hippocampal parvalbumin-positive interneurons did not differ between groups, HI reduced the number of CA1 interneuron dendrites. Piglets with more incorrect turns had greater CA3 neuron loss, and piglets that took longer in the maze had fewer CA3 interneurons. The number of putamen neurons was unrelated to T-maze or beam performance. We conclude that neonatal HI causes hippocampal CA3 neuron loss, CA1 interneuron dendritic attrition, and putamen neuron loss at 1-month recovery. The spatial T-maze identifies learning and memory deficits that are related to loss of CA3 pyramidal neurons and fewer parvalbumin-positive interneurons independent of putamen injury." @default.
- W2938508587 created "2019-04-25" @default.
- W2938508587 creator A5006130007 @default.
- W2938508587 creator A5021031418 @default.
- W2938508587 creator A5024878520 @default.
- W2938508587 creator A5032610896 @default.
- W2938508587 creator A5059454123 @default.
- W2938508587 creator A5074537745 @default.
- W2938508587 date "2019-09-01" @default.
- W2938508587 modified "2023-10-17" @default.
- W2938508587 title "Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition" @default.
- W2938508587 cites W1969949618 @default.
- W2938508587 cites W1973590951 @default.
- W2938508587 cites W1974976194 @default.
- W2938508587 cites W1981360487 @default.
- W2938508587 cites W1990837918 @default.
- W2938508587 cites W1996421030 @default.
- W2938508587 cites W1997229283 @default.
- W2938508587 cites W2001116239 @default.
- W2938508587 cites W2002087655 @default.
- W2938508587 cites W2003658189 @default.
- W2938508587 cites W2003731009 @default.
- W2938508587 cites W2022008450 @default.
- W2938508587 cites W2030119843 @default.
- W2938508587 cites W2030603659 @default.
- W2938508587 cites W2031412579 @default.
- W2938508587 cites W2035535900 @default.
- W2938508587 cites W2038813826 @default.
- W2938508587 cites W2041156964 @default.
- W2938508587 cites W2053618427 @default.
- W2938508587 cites W2055829587 @default.
- W2938508587 cites W2069139995 @default.
- W2938508587 cites W2074898131 @default.
- W2938508587 cites W2087104516 @default.
- W2938508587 cites W2089648703 @default.
- W2938508587 cites W2090955970 @default.
- W2938508587 cites W2091536100 @default.
- W2938508587 cites W2096240659 @default.
- W2938508587 cites W2102681682 @default.
- W2938508587 cites W2103322364 @default.
- W2938508587 cites W2103712981 @default.
- W2938508587 cites W2115585096 @default.
- W2938508587 cites W2124228927 @default.
- W2938508587 cites W2131538341 @default.
- W2938508587 cites W2132489993 @default.
- W2938508587 cites W2156779369 @default.
- W2938508587 cites W2162322073 @default.
- W2938508587 cites W2209423325 @default.
- W2938508587 cites W2342456556 @default.
- W2938508587 cites W2519545591 @default.
- W2938508587 cites W2604169957 @default.
- W2938508587 cites W2604540808 @default.
- W2938508587 cites W2614045147 @default.
- W2938508587 cites W2803919537 @default.
- W2938508587 cites W2886139975 @default.
- W2938508587 cites W2889199320 @default.
- W2938508587 cites W2891354340 @default.
- W2938508587 cites W2895341076 @default.
- W2938508587 cites W2897795078 @default.
- W2938508587 cites W2945352598 @default.
- W2938508587 cites W2949375991 @default.
- W2938508587 doi "https://doi.org/10.1016/j.bbr.2019.111921" @default.
- W2938508587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6545140" @default.
- W2938508587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31009645" @default.
- W2938508587 hasPublicationYear "2019" @default.
- W2938508587 type Work @default.
- W2938508587 sameAs 2938508587 @default.
- W2938508587 citedByCount "11" @default.
- W2938508587 countsByYear W29385085872019 @default.
- W2938508587 countsByYear W29385085872020 @default.
- W2938508587 countsByYear W29385085872021 @default.
- W2938508587 countsByYear W29385085872022 @default.
- W2938508587 countsByYear W29385085872023 @default.
- W2938508587 crossrefType "journal-article" @default.
- W2938508587 hasAuthorship W2938508587A5006130007 @default.
- W2938508587 hasAuthorship W2938508587A5021031418 @default.
- W2938508587 hasAuthorship W2938508587A5024878520 @default.
- W2938508587 hasAuthorship W2938508587A5032610896 @default.
- W2938508587 hasAuthorship W2938508587A5059454123 @default.
- W2938508587 hasAuthorship W2938508587A5074537745 @default.
- W2938508587 hasBestOaLocation W29385085872 @default.
- W2938508587 hasConcept C109344038 @default.
- W2938508587 hasConcept C12515866 @default.
- W2938508587 hasConcept C141547260 @default.
- W2938508587 hasConcept C148762608 @default.
- W2938508587 hasConcept C15744967 @default.
- W2938508587 hasConcept C169760540 @default.
- W2938508587 hasConcept C17077164 @default.
- W2938508587 hasConcept C2776464000 @default.
- W2938508587 hasConcept C2778794669 @default.
- W2938508587 hasConcept C2779296341 @default.
- W2938508587 hasConcept C2779714222 @default.
- W2938508587 hasConcept C44752575 @default.
- W2938508587 hasConceptScore W2938508587C109344038 @default.
- W2938508587 hasConceptScore W2938508587C12515866 @default.
- W2938508587 hasConceptScore W2938508587C141547260 @default.
- W2938508587 hasConceptScore W2938508587C148762608 @default.
- W2938508587 hasConceptScore W2938508587C15744967 @default.