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• W2938509327 abstract "Supernumerary B chromosomes are dispensable elements found in several groups of eukaryotes, and their impacts in host organisms are not clear. The cichlid fish Astatotilapia latifasciata presents one or two large metacentric B chromosomes. These elements affect the transcription of several classes of RNAs. Here, we evaluated the epigenetic DNA modification status of B chromosomes using immunocytogenetics and assessed the impact of B chromosome presence on the global contents of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) and the molecular mechanisms underlying these variations. We found that the B chromosome of A. latifasciata has an active pattern of DNA epimarks, and its presence promotes the loss of 5mC in gonads of females with B chromosome (FB+) and promotes the loss of 5hmC in the muscle of males with the B element (MB+). Based on the transcriptional quantification of DNA modification genes (dnmt, tet, and tdg) and their candidate regulators (idh genes, microRNAs, and long non-coding RNAs) and on RNA-protein interaction prediction, we suggest the occurrence of passive demethylation in gonads of FB+ and 5hmC loss by Tet inhibition or by 5hmC oxidation in MB+ muscle. We suggest that these results can also explain the previously reported variations in the transcription levels of several classes of RNA depending on B chromosome presence. The DNA modifications detected here are also influenced by sex. Although the correlation between B chromosomes and sex has been previously reported, it remains unexplained. The B chromosome of A. latifasciata seems to be active and impacts cell physiology in a very complex way, including at the epigenetic level." @default.
• W2938509327 created "2019-04-25" @default.
• W2938509327 creator A5002764942 @default.
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• W2938509327 creator A5091324452 @default.
• W2938509327 date "2019-04-12" @default.
• W2938509327 modified "2023-10-03" @default.
• W2938509327 title "Epigenetic DNA Modifications Are Correlated With B Chromosomes and Sex in the Cichlid Astatotilapia latifasciata" @default.
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• W2938509327 doi "https://doi.org/10.3389/fgene.2019.00324" @default.
• W2938509327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6474290" @default.
• W2938509327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31031803" @default.
• W2938509327 hasPublicationYear "2019" @default.
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