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- W2938518288 abstract "The innate immune system provides a first line of defense against invading pathogens, in which the pattern recognition receptors (PRR) recognize pathogen-associated molecular patterns (PAMP) and initiate the downstream signaling pathways to eliminate the encountered pathogens. There are two main classes of such signaling pathways: NOD-like receptor (NLR) signaling pathway and Toll-like receptor (TLR) signaling pathway. The microbial pathogens under selective pressure have evolved numerous mechanisms to avoid and/or manipulate the NLR and TLR signal transduction for survival and replication. To evade the NLR signaling pathway, pathogens interfere and/or inhibit inflammasome activation in innate immune cells by producing virulence factors or reducing PAMPs expression. The mechanisms for pathogens to evade TLR signaling pathway include: inhibition of mitogen activated protein kinases (MAPKs) cascade reaction, inhibition of NF-КB activation, and interference of down-stream signal transduction by producing Toll/interleukin-1 receptor (TIR)-containing proteins which bind directly with TLRs or adaptor proteins in the signaling pathway." @default.
- W2938518288 created "2019-04-25" @default.
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- W2938518288 date "2017-03-25" @default.
- W2938518288 modified "2023-09-25" @default.
- W2938518288 title "[Progress on mechanisms for pathogensto evade NOD-like receptor and Toll-like receptor signaling pathways]." @default.
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- W2938518288 doi "https://doi.org/10.3785/j.issn.1008-9292.2017.04.16" @default.
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