FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938543030> ?p ?o ?g. }

• W2938543030 abstract "Abstract Nasopharyngeal carcinoma (NPC) is the most prevalent head and neck malignancy in South China and Southeast Asia. The main NPC treatment strategy is radiotherapy. However, recurrence resulting from radioresistance is a leading clinical bottleneck. Revealing the mechanism of NPC radioresistance would help improve the therapeutic effect. Here, our work reveals that TRIM21 (tripartite motif–containing 21) functions as an oncogene in NPC progression, and its ablation increases NPC cell radiosensitivity. Further analysis indicated that TRIM21 represses TP53 expression by mediating GMPS (guanine monophosphate synthase) ubiquitination and degradation after ionizing radiation. Mass spectrometry and co-immunoprecipitation showed that SERPINB5 (serpin family B member 5) interacts with both TRIM21 and GMPS. Epistatic analysis showed that SERPINB5 acts as an adaptor to recruit GMPS and introduce TRIM21 for ubiquitination. The in vitro and in vivo results validated the finding that SERPINB5 promotes NPC cell radioresistance. Furthermore, immunohistochemistry indicated that radioresistant patients have higher SERPINB5 expression. Overall, our data show that TRIM21–SERPINB5-mediated GMPS degradation facilitates TP53 repression, which promotes the radioresistance of NPC cells." @default.
• W2938543030 created "2019-04-25" @default.
• W2938543030 creator A5029299515 @default.
• W2938543030 creator A5045545412 @default.
• W2938543030 creator A5048287146 @default.
• W2938543030 creator A5049147188 @default.
• W2938543030 creator A5054603016 @default.
• W2938543030 creator A5058333204 @default.
• W2938543030 creator A5058725926 @default.
• W2938543030 creator A5065047387 @default.
• W2938543030 creator A5068036067 @default.
• W2938543030 creator A5070961992 @default.
• W2938543030 creator A5089785494 @default.
• W2938543030 date "2019-04-16" @default.
• W2938543030 modified "2023-09-23" @default.
• W2938543030 title "TRIM21–SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis" @default.
• W2938543030 cites W1950155832 @default.
• W2938543030 cites W1980300257 @default.
• W2938543030 cites W1981570640 @default.
• W2938543030 cites W1985129350 @default.
• W2938543030 cites W1990365150 @default.
• W2938543030 cites W1991457843 @default.
• W2938543030 cites W1992255689 @default.
• W2938543030 cites W2004292818 @default.
• W2938543030 cites W2023723107 @default.
• W2938543030 cites W2032063175 @default.
• W2938543030 cites W2041675187 @default.
• W2938543030 cites W2062338389 @default.
• W2938543030 cites W2074630299 @default.
• W2938543030 cites W2079076511 @default.
• W2938543030 cites W2095424116 @default.
• W2938543030 cites W2106787323 @default.
• W2938543030 cites W2109511371 @default.
• W2938543030 cites W2114410768 @default.
• W2938543030 cites W2129750560 @default.
• W2938543030 cites W2148593237 @default.
• W2938543030 cites W2152379289 @default.
• W2938543030 cites W2164683872 @default.
• W2938543030 cites W2169305817 @default.
• W2938543030 cites W2216966119 @default.
• W2938543030 cites W2302813135 @default.
• W2938543030 cites W2379126722 @default.
• W2938543030 cites W2604577110 @default.
• W2938543030 cites W2906384898 @default.
• W2938543030 cites W4211070369 @default.
• W2938543030 cites W4294112996 @default.
• W2938543030 doi "https://doi.org/10.1101/609743" @default.
• W2938543030 hasPublicationYear "2019" @default.
• W2938543030 type Work @default.
• W2938543030 sameAs 2938543030 @default.
• W2938543030 citedByCount "0" @default.
• W2938543030 crossrefType "posted-content" @default.
• W2938543030 hasAuthorship W2938543030A5029299515 @default.
• W2938543030 hasAuthorship W2938543030A5045545412 @default.
• W2938543030 hasAuthorship W2938543030A5048287146 @default.
• W2938543030 hasAuthorship W2938543030A5049147188 @default.
• W2938543030 hasAuthorship W2938543030A5054603016 @default.
• W2938543030 hasAuthorship W2938543030A5058333204 @default.
• W2938543030 hasAuthorship W2938543030A5058725926 @default.
• W2938543030 hasAuthorship W2938543030A5065047387 @default.
• W2938543030 hasAuthorship W2938543030A5068036067 @default.
• W2938543030 hasAuthorship W2938543030A5070961992 @default.
• W2938543030 hasAuthorship W2938543030A5089785494 @default.
• W2938543030 hasBestOaLocation W29385430301 @default.
• W2938543030 hasConcept C126322002 @default.
• W2938543030 hasConcept C173396325 @default.
• W2938543030 hasConcept C185592680 @default.
• W2938543030 hasConcept C190283241 @default.
• W2938543030 hasConcept C2778997737 @default.
• W2938543030 hasConcept C502942594 @default.
• W2938543030 hasConcept C509974204 @default.
• W2938543030 hasConcept C54355233 @default.
• W2938543030 hasConcept C58962609 @default.
• W2938543030 hasConcept C71924100 @default.
• W2938543030 hasConcept C81885089 @default.
• W2938543030 hasConcept C86803240 @default.
• W2938543030 hasConceptScore W2938543030C126322002 @default.
• W2938543030 hasConceptScore W2938543030C173396325 @default.
• W2938543030 hasConceptScore W2938543030C185592680 @default.
• W2938543030 hasConceptScore W2938543030C190283241 @default.
• W2938543030 hasConceptScore W2938543030C2778997737 @default.
• W2938543030 hasConceptScore W2938543030C502942594 @default.
• W2938543030 hasConceptScore W2938543030C509974204 @default.
• W2938543030 hasConceptScore W2938543030C54355233 @default.
• W2938543030 hasConceptScore W2938543030C58962609 @default.
• W2938543030 hasConceptScore W2938543030C71924100 @default.
• W2938543030 hasConceptScore W2938543030C81885089 @default.
• W2938543030 hasConceptScore W2938543030C86803240 @default.
• W2938543030 hasLocation W29385430301 @default.
• W2938543030 hasLocation W29385430302 @default.
• W2938543030 hasOpenAccess W2938543030 @default.
• W2938543030 hasPrimaryLocation W29385430301 @default.
• W2938543030 hasRelatedWork W2307349625 @default.
• W2938543030 hasRelatedWork W2317043853 @default.
• W2938543030 hasRelatedWork W2369568433 @default.
• W2938543030 hasRelatedWork W2414026187 @default.
• W2938543030 hasRelatedWork W2765176484 @default.
• W2938543030 hasRelatedWork W2790459024 @default.
• W2938543030 hasRelatedWork W2889926123 @default.
• W2938543030 hasRelatedWork W2893509582 @default.

• next