FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938579726> ?p ?o ?g. }

• W2938579726 abstract "Complex regional pain syndrome (CRPS) is a debilitating condition where trauma to a limb results in devastating persistent pain that is disproportionate to the initial injury. The pathophysiology of CRPS remains unknown; however, accumulating evidence suggests it is an immunoneurological disorder, especially in light of evidence of auto-antibodies in ~ 30% of patients. Despite this, a systematic assessment of all circulating leukocyte populations in CRPS has never been performed.We characterised 14 participants as meeting the Budapest clinical criteria for CRPS and assessed their pain ratings and psychological state using a series of questionnaires. Next, we performed immunophenotyping on blood samples from the 14 CRPS participants as well as 14 healthy pain-free controls using mass cytometry. Using a panel of 38 phenotypic and activation markers, we characterised the numbers and intracellular activation status of all major leukocyte populations using manual gating strategies and unsupervised cluster analysis.We have shown expansion and activation of several distinct populations of central memory T lymphocytes in CRPS. The number of central memory CD8+ T cells was increased 2.15-fold; furthermore, this cell group had increased phosphorylation of NFkB and STAT1 compared to controls. Regarding central memory CD4+ T lymphocytes, the number of Th1 and Treg cells was increased 4.98-fold and 2.18-fold respectively, with increased phosphorylation of NFkB in both populations. We also found decreased numbers of CD1c+ myeloid dendritic cells, although with increased p38 phosphorylation. These changes could indicate dendritic cell tissue trafficking, as well as their involvement in lymphocyte activation.These findings represent the first mass cytometry immunophenotyping study in any chronic pain state and provide preliminary evidence of an antigen-mediated T lymphocyte response in CRPS. In particular, the presence of increased numbers of long-lived central memory CD4+ and CD8+ T lymphocytes with increased activation of pro-inflammatory signalling pathways may indicate ongoing inflammation and cellular damage in CRPS." @default.
• W2938579726 created "2019-04-25" @default.
• W2938579726 creator A5001801516 @default.
• W2938579726 creator A5004715557 @default.
• W2938579726 creator A5006212636 @default.
• W2938579726 creator A5024534614 @default.
• W2938579726 creator A5050720403 @default.
• W2938579726 creator A5051710748 @default.
• W2938579726 creator A5056553498 @default.
• W2938579726 creator A5069330813 @default.
• W2938579726 date "2019-03-18" @default.
• W2938579726 modified "2023-10-17" @default.
• W2938579726 title "Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome" @default.
• W2938579726 cites W1492728201 @default.
• W2938579726 cites W159084986 @default.
• W2938579726 cites W1629158096 @default.
• W2938579726 cites W1807865801 @default.
• W2938579726 cites W1965431554 @default.
• W2938579726 cites W1971908211 @default.
• W2938579726 cites W1973439033 @default.
• W2938579726 cites W1981912417 @default.
• W2938579726 cites W1989273697 @default.
• W2938579726 cites W1990458269 @default.
• W2938579726 cites W1991929293 @default.
• W2938579726 cites W1993835819 @default.
• W2938579726 cites W1997863210 @default.
• W2938579726 cites W1999602464 @default.
• W2938579726 cites W2000495010 @default.
• W2938579726 cites W2000827897 @default.
• W2938579726 cites W2008229424 @default.
• W2938579726 cites W2014313724 @default.
• W2938579726 cites W2014346117 @default.
• W2938579726 cites W2015783022 @default.
• W2938579726 cites W2016844667 @default.
• W2938579726 cites W2018355952 @default.
• W2938579726 cites W2021043915 @default.
• W2938579726 cites W2022433082 @default.
• W2938579726 cites W2035099246 @default.
• W2938579726 cites W2036709667 @default.
• W2938579726 cites W2038426170 @default.
• W2938579726 cites W2039675417 @default.
• W2938579726 cites W2040721374 @default.
• W2938579726 cites W2055177114 @default.
• W2938579726 cites W2061678130 @default.
• W2938579726 cites W2064593553 @default.
• W2938579726 cites W2064851589 @default.
• W2938579726 cites W2065337757 @default.
• W2938579726 cites W2067207728 @default.
• W2938579726 cites W2067212451 @default.
• W2938579726 cites W2072016770 @default.
• W2938579726 cites W2073256527 @default.
• W2938579726 cites W2084547941 @default.
• W2938579726 cites W2091218020 @default.
• W2938579726 cites W2091629304 @default.
• W2938579726 cites W2092758924 @default.
• W2938579726 cites W2094172517 @default.
• W2938579726 cites W2095335650 @default.
• W2938579726 cites W2095708680 @default.
• W2938579726 cites W2104910525 @default.
• W2938579726 cites W2105000783 @default.
• W2938579726 cites W2111964682 @default.
• W2938579726 cites W2116634463 @default.
• W2938579726 cites W2118201373 @default.
• W2938579726 cites W2119278692 @default.
• W2938579726 cites W2119900303 @default.
• W2938579726 cites W2122096201 @default.
• W2938579726 cites W2123128921 @default.
• W2938579726 cites W2124537265 @default.
• W2938579726 cites W2126010781 @default.
• W2938579726 cites W2128202887 @default.
• W2938579726 cites W2128387393 @default.
• W2938579726 cites W2135208822 @default.
• W2938579726 cites W2138452800 @default.
• W2938579726 cites W2142603939 @default.
• W2938579726 cites W2145508404 @default.
• W2938579726 cites W2147599802 @default.
• W2938579726 cites W2148452875 @default.
• W2938579726 cites W2164791359 @default.
• W2938579726 cites W2167431796 @default.
• W2938579726 cites W2201871812 @default.
• W2938579726 cites W2275274326 @default.
• W2938579726 cites W2337481285 @default.
• W2938579726 cites W2340128484 @default.
• W2938579726 cites W2342330592 @default.
• W2938579726 cites W2344980370 @default.
• W2938579726 cites W2346039638 @default.
• W2938579726 cites W2404493695 @default.
• W2938579726 cites W2414055539 @default.
• W2938579726 cites W2485014704 @default.
• W2938579726 cites W2524926856 @default.
• W2938579726 cites W2535664532 @default.
• W2938579726 cites W2536659826 @default.
• W2938579726 cites W2619133778 @default.
• W2938579726 cites W2743268753 @default.
• W2938579726 cites W2748955986 @default.
• W2938579726 cites W2751474624 @default.
• W2938579726 cites W2768786783 @default.
• W2938579726 cites W2797830756 @default.
• W2938579726 cites W2800585341 @default.
• W2938579726 cites W2801872281 @default.

• next