Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938585684> ?p ?o ?g. }
- W2938585684 endingPage "e0007324" @default.
- W2938585684 startingPage "e0007324" @default.
- W2938585684 abstract "Chagas Disease (CD) is an anthropozoonosis caused by Trypanosoma cruzi. With complex pathophysiology and variable clinical presentation, CD outcome can be influenced by parasite persistence and the host immune response. Complement activation is one of the primary defense mechanisms against pathogens, which can be initiated via pathogen recognition by pattern recognition molecules (PRMs). Collectin-11 is a multifunctional soluble PRM lectin, widely distributed throughout the body, with important participation in host defense, homeostasis, and embryogenesis. In complex with mannose-binding lectin-associated serine proteases (MASPs), collectin-11 may initiate the activation of complement, playing a role against pathogens, including T. cruzi. In this study, collectin-11 plasma levels and COLEC11 variants in exon 7 were assessed in a Brazilian cohort of 251 patients with chronic CD and 108 healthy controls. Gene-gene interactions between COLEC11 and MASP2 variants were analyzed. Collectin-11 levels were significantly decreased in CD patients compared to controls (p<0.0001). The allele rs7567833G, the genotypes rs7567833AG and rs7567833GG, and the COLEC11*GGC haplotype were related to T. cruzi infection and clinical progression towards symptomatic CD. COLEC11 and MASP2*CD risk genotypes were associated with cardiomyopathy (p = 0.014; OR 9.3, 95% CI 1.2–74) and with the cardiodigestive form of CD (p = 0.005; OR 15.2, 95% CI 1.7–137), suggesting that both loci act synergistically in immune modulation of the disease. The decreased levels of collectin-11 in CD patients may be associated with the disease process. The COLEC11 variant rs7567833G and also the COLEC11 and MASP2*CD risk genotype interaction were associated with the pathophysiology of CD." @default.
- W2938585684 created "2019-04-25" @default.
- W2938585684 creator A5035148816 @default.
- W2938585684 creator A5038493283 @default.
- W2938585684 creator A5040967172 @default.
- W2938585684 creator A5049916735 @default.
- W2938585684 creator A5059368668 @default.
- W2938585684 creator A5067621342 @default.
- W2938585684 creator A5073119907 @default.
- W2938585684 creator A5074761424 @default.
- W2938585684 date "2019-04-17" @default.
- W2938585684 modified "2023-09-23" @default.
- W2938585684 title "Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas Disease" @default.
- W2938585684 cites W1557343619 @default.
- W2938585684 cites W1683278196 @default.
- W2938585684 cites W1862091519 @default.
- W2938585684 cites W1970365484 @default.
- W2938585684 cites W1971512152 @default.
- W2938585684 cites W1972043575 @default.
- W2938585684 cites W1980740976 @default.
- W2938585684 cites W1987507232 @default.
- W2938585684 cites W1989004749 @default.
- W2938585684 cites W1995744610 @default.
- W2938585684 cites W2000456429 @default.
- W2938585684 cites W2011278079 @default.
- W2938585684 cites W2015351663 @default.
- W2938585684 cites W2030385147 @default.
- W2938585684 cites W2030545744 @default.
- W2938585684 cites W2040087478 @default.
- W2938585684 cites W2043296206 @default.
- W2938585684 cites W2056833905 @default.
- W2938585684 cites W2059145105 @default.
- W2938585684 cites W2060358778 @default.
- W2938585684 cites W2060705235 @default.
- W2938585684 cites W2064648040 @default.
- W2938585684 cites W2065850593 @default.
- W2938585684 cites W2066001051 @default.
- W2938585684 cites W2078281513 @default.
- W2938585684 cites W2086706156 @default.
- W2938585684 cites W2099589970 @default.
- W2938585684 cites W2119211538 @default.
- W2938585684 cites W2121783932 @default.
- W2938585684 cites W2125581925 @default.
- W2938585684 cites W2129586493 @default.
- W2938585684 cites W2132387264 @default.
- W2938585684 cites W2135250894 @default.
- W2938585684 cites W2136220283 @default.
- W2938585684 cites W2140520351 @default.
- W2938585684 cites W2142490500 @default.
- W2938585684 cites W2145733117 @default.
- W2938585684 cites W2161358913 @default.
- W2938585684 cites W2162915566 @default.
- W2938585684 cites W2170304291 @default.
- W2938585684 cites W2217809488 @default.
- W2938585684 cites W2224491527 @default.
- W2938585684 cites W2413761099 @default.
- W2938585684 cites W2473376802 @default.
- W2938585684 cites W2542867039 @default.
- W2938585684 cites W2609640634 @default.
- W2938585684 cites W2782254684 @default.
- W2938585684 cites W2905452503 @default.
- W2938585684 cites W4210980497 @default.
- W2938585684 doi "https://doi.org/10.1371/journal.pntd.0007324" @default.
- W2938585684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6488100" @default.
- W2938585684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30995222" @default.
- W2938585684 hasPublicationYear "2019" @default.
- W2938585684 type Work @default.
- W2938585684 sameAs 2938585684 @default.
- W2938585684 citedByCount "6" @default.
- W2938585684 countsByYear W29385856842019 @default.
- W2938585684 countsByYear W29385856842020 @default.
- W2938585684 countsByYear W29385856842021 @default.
- W2938585684 countsByYear W29385856842023 @default.
- W2938585684 crossrefType "journal-article" @default.
- W2938585684 hasAuthorship W2938585684A5035148816 @default.
- W2938585684 hasAuthorship W2938585684A5038493283 @default.
- W2938585684 hasAuthorship W2938585684A5040967172 @default.
- W2938585684 hasAuthorship W2938585684A5049916735 @default.
- W2938585684 hasAuthorship W2938585684A5059368668 @default.
- W2938585684 hasAuthorship W2938585684A5067621342 @default.
- W2938585684 hasAuthorship W2938585684A5073119907 @default.
- W2938585684 hasAuthorship W2938585684A5074761424 @default.
- W2938585684 hasBestOaLocation W29385856841 @default.
- W2938585684 hasConcept C111684460 @default.
- W2938585684 hasConcept C112418997 @default.
- W2938585684 hasConcept C133493029 @default.
- W2938585684 hasConcept C136449434 @default.
- W2938585684 hasConcept C189413060 @default.
- W2938585684 hasConcept C189446657 @default.
- W2938585684 hasConcept C203014093 @default.
- W2938585684 hasConcept C203880312 @default.
- W2938585684 hasConcept C2780758401 @default.
- W2938585684 hasConcept C86803240 @default.
- W2938585684 hasConcept C8891405 @default.
- W2938585684 hasConceptScore W2938585684C111684460 @default.
- W2938585684 hasConceptScore W2938585684C112418997 @default.
- W2938585684 hasConceptScore W2938585684C133493029 @default.
- W2938585684 hasConceptScore W2938585684C136449434 @default.