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• W2938588827 abstract "Salmonella Typhimurium is one of the leading causes of foodborne bacterial infection. Nevertheless, how Salmonella adapts to distinct types of host cells during infection remains poorly understood. By contrasting intracellular Salmonella proteomes from both infected macrophages and epithelial cells, we found striking proteomic signatures specific to particular types of host cells. Notably, Salmonella proteomic remodeling exhibited quicker kinetics in macrophages than in epithelial cells with respect to bacterial virulence and flagellar and chemotaxis systems. Furthermore, we unveiled high levels of induction of bacterial histidine biosynthesis in macrophages but not in epithelial cells, which is attributable to differing intracellular levels of this amino acid. Intriguingly, we found that a defective hisG gene renders a Salmonella strain hypersensitive to histidine shortage in macrophages. Overall, our work reveals specific Salmonella adaptation mechanisms in distinct host cells, which should aid in the development of novel anti-infection strategies." @default.
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• W2938588827 date "2019-04-30" @default.
• W2938588827 modified "2023-10-14" @default.
• W2938588827 title "<i>Salmonella</i> Proteomic Profiling during Infection Distinguishes the Intracellular Environment of Host Cells" @default.
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• W2938588827 doi "https://doi.org/10.1128/msystems.00314-18" @default.
• W2938588827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6456673" @default.
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