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- W2938641131 endingPage "282" @default.
- W2938641131 startingPage "271" @default.
- W2938641131 abstract "Over the past century, the notion that vitamin C can be used to treat cancer has generated much controversy. However, new knowledge regarding the pharmacokinetic properties of vitamin C and recent high-profile preclinical studies have revived interest in the utilization of high-dose vitamin C for cancer treatment. Studies have shown that pharmacological vitamin C targets many of the mechanisms that cancer cells utilize for their survival and growth. In this Opinion article, we discuss how vitamin C can target three vulnerabilities many cancer cells share: redox imbalance, epigenetic reprogramming and oxygen-sensing regulation. Although the mechanisms and predictive biomarkers that we discuss need to be validated in well-controlled clinical trials, these new discoveries regarding the anticancer properties of vitamin C are promising to help identify patient populations that may benefit the most from high-dose vitamin C therapy, developing effective combination strategies and improving the overall design of future vitamin C clinical trials for various types of cancer." @default.
- W2938641131 created "2019-04-25" @default.
- W2938641131 creator A5012858665 @default.
- W2938641131 creator A5048833289 @default.
- W2938641131 creator A5078274293 @default.
- W2938641131 creator A5084981510 @default.
- W2938641131 date "2019-04-09" @default.
- W2938641131 modified "2023-10-14" @default.
- W2938641131 title "Targeting cancer vulnerabilities with high-dose vitamin C" @default.
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