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- W2938673434 abstract "In contrast to the well-characterized leukocytic compartment in human skin, relatively little is known about the one residing in the fat layer beneath. To address this issue, we collected thigh-liposuction-derived subcutaneous white adipose tissue (SWAT; n=14) from healthy young women, normal skin (n=7) and blood (n=7), isolated the leukocytes from these compartments, characterized them by FACS and subjected them to cytokine stimulation assays. In addition, we performed in situmulticolor immunofluorescence stainings. We found major differences between SWAT and skin leukocytes: while T cells outnumbered mononuclear phagocytes in the skin, macrophages constituted the largest population (>50%) among SWAT-leukocytes, followed by T cells (ca. 25%) and several minor leukocyte subsets such as natural killer cells, dendritic cells, type 2 innate lymphoid cells and eosinophils. These leukocytes were essentially confined to connective tissue septa separating individual lobules of adipose tissue. The majority of SWAT-macrophages exhibited an M2 phenotype. Most SWAT-T cells, composed of about equal proportions of type 1- and type 2-polarized cells, belonged to the memory subset and half of them were tissue-resident (mostly CD69+CD103+). Th2-cytokine producing cells predominated among ILCs. Our data constitute the basis for further experiments investigating features and functions of SWAT-leukocytes under physiologic and pathologic conditions and studying the interplay with their symbionts." @default.
- W2938673434 created "2019-04-25" @default.
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- W2938673434 date "2019-05-01" @default.
- W2938673434 modified "2023-09-25" @default.
- W2938673434 title "055 The leukocyte compartment of subcutaneous white adipose tissue: major differences as to skin and blood" @default.
- W2938673434 doi "https://doi.org/10.1016/j.jid.2019.03.131" @default.
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