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• W2938686566 abstract "Three new rare cyclopiane diterpenes (1–3), together with thirteen known compounds (4–16), were isolated and identified from a sea sediment-derived fungus Penicillium sp. TJ403-2. The planar and relative structures of compounds 1–3 were elucidated by HRESIMS, one- and two-dimensional NMR analyses, and their absolute configurations were further established by X-ray crystallography experiment. Compounds 1–3 were evaluated for the anti-inflammatory activity against LPS-induced NO production, and compound 1 showed notable inhibitory potency with an IC50 value of 2.19 ± 0.25 μmol/L, which was three fold lower than the positive control indomethacin (IC50 = 8.76 ± 0.92 μmol/L). Further Western blot and immunofluorescence experiments demonstrated its mechanism of action to be that 1 inhibited the NF-κB-activated pathway, highlighting it as a promising starting point for the development of new anti-inflammatory agents." @default.
• W2938686566 created "2019-04-25" @default.
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• W2938686566 date "2020-01-01" @default.
• W2938686566 modified "2023-10-18" @default.
• W2938686566 title "New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungus Penicillium sp. TJ403-2" @default.
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• W2938686566 doi "https://doi.org/10.1016/j.cclet.2019.04.036" @default.
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