Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938721057> ?p ?o ?g. }
- W2938721057 endingPage "1610" @default.
- W2938721057 startingPage "1596" @default.
- W2938721057 abstract "A number of significant muscle diseases, such as cachexia, sarcopenia, systemic chronic inflammation, along with inflammatory myopathies share TNF-α-dominated inflammation in their pathogenesis. In addition, inflammatory episodes may increase susceptibility to drug toxicity. To assess the effect of TNF-α-induced inflammation on drug responses, we engineered 3D, human skeletal myobundles, chronically exposed them to TNF-α during maturation, and measured the combined response of TNF-α and the chemotherapeutic doxorubicin on muscle function. First, the myobundle inflammatory environment was characterized by assessing the effects of TNF-α on 2D human skeletal muscle cultures and 3D human myobundles. High doses of TNF-α inhibited maturation in human 2D cultures and maturation and function in 3D myobundles. Then, a tetanus force dose–response curve was constructed to characterize doxorubicin’s effects on function alone. The combination of TNF-α and 10 nM doxorubicin exhibited a synergistic effect on both twitch and tetanus force production. Overall, the results demonstrated that inflammation of a 3D, human skeletal muscle inflammatory system alters the response to doxorubicin." @default.
- W2938721057 created "2019-04-25" @default.
- W2938721057 creator A5005893938 @default.
- W2938721057 creator A5017140951 @default.
- W2938721057 creator A5017226394 @default.
- W2938721057 creator A5023772133 @default.
- W2938721057 creator A5035808490 @default.
- W2938721057 creator A5037002121 @default.
- W2938721057 creator A5055562476 @default.
- W2938721057 creator A5061496543 @default.
- W2938721057 creator A5067472549 @default.
- W2938721057 creator A5073339227 @default.
- W2938721057 creator A5077876381 @default.
- W2938721057 date "2019-04-08" @default.
- W2938721057 modified "2023-09-26" @default.
- W2938721057 title "Modeling the Effect of TNF-α upon Drug-Induced Toxicity in Human, Tissue-Engineered Myobundles" @default.
- W2938721057 cites W132063385 @default.
- W2938721057 cites W1543790510 @default.
- W2938721057 cites W1845511895 @default.
- W2938721057 cites W1865608113 @default.
- W2938721057 cites W1964072247 @default.
- W2938721057 cites W1966327507 @default.
- W2938721057 cites W1981029700 @default.
- W2938721057 cites W1983740089 @default.
- W2938721057 cites W1983763758 @default.
- W2938721057 cites W1986437772 @default.
- W2938721057 cites W1987515217 @default.
- W2938721057 cites W1997524040 @default.
- W2938721057 cites W2008236720 @default.
- W2938721057 cites W2009798744 @default.
- W2938721057 cites W2021131539 @default.
- W2938721057 cites W2021345028 @default.
- W2938721057 cites W2024718054 @default.
- W2938721057 cites W2026192447 @default.
- W2938721057 cites W2040684663 @default.
- W2938721057 cites W2042829874 @default.
- W2938721057 cites W2045038402 @default.
- W2938721057 cites W2057070304 @default.
- W2938721057 cites W2060065785 @default.
- W2938721057 cites W2062770015 @default.
- W2938721057 cites W2064720249 @default.
- W2938721057 cites W2076277955 @default.
- W2938721057 cites W2106926141 @default.
- W2938721057 cites W2121082639 @default.
- W2938721057 cites W2127920599 @default.
- W2938721057 cites W2128746574 @default.
- W2938721057 cites W2132949875 @default.
- W2938721057 cites W2136442269 @default.
- W2938721057 cites W2150387617 @default.
- W2938721057 cites W2158095398 @default.
- W2938721057 cites W2161591738 @default.
- W2938721057 cites W2167108511 @default.
- W2938721057 cites W2169025971 @default.
- W2938721057 cites W2171103133 @default.
- W2938721057 cites W2226324689 @default.
- W2938721057 cites W2275856918 @default.
- W2938721057 cites W2295314306 @default.
- W2938721057 cites W2343834286 @default.
- W2938721057 cites W2470932240 @default.
- W2938721057 cites W2600933586 @default.
- W2938721057 cites W37880063 @default.
- W2938721057 cites W4212819131 @default.
- W2938721057 cites W4240717991 @default.
- W2938721057 cites W810857154 @default.
- W2938721057 doi "https://doi.org/10.1007/s10439-019-02263-8" @default.
- W2938721057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6559943" @default.
- W2938721057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30963383" @default.
- W2938721057 hasPublicationYear "2019" @default.
- W2938721057 type Work @default.
- W2938721057 sameAs 2938721057 @default.
- W2938721057 citedByCount "5" @default.
- W2938721057 countsByYear W29387210572020 @default.
- W2938721057 countsByYear W29387210572021 @default.
- W2938721057 countsByYear W29387210572022 @default.
- W2938721057 crossrefType "journal-article" @default.
- W2938721057 hasAuthorship W2938721057A5005893938 @default.
- W2938721057 hasAuthorship W2938721057A5017140951 @default.
- W2938721057 hasAuthorship W2938721057A5017226394 @default.
- W2938721057 hasAuthorship W2938721057A5023772133 @default.
- W2938721057 hasAuthorship W2938721057A5035808490 @default.
- W2938721057 hasAuthorship W2938721057A5037002121 @default.
- W2938721057 hasAuthorship W2938721057A5055562476 @default.
- W2938721057 hasAuthorship W2938721057A5061496543 @default.
- W2938721057 hasAuthorship W2938721057A5067472549 @default.
- W2938721057 hasAuthorship W2938721057A5073339227 @default.
- W2938721057 hasAuthorship W2938721057A5077876381 @default.
- W2938721057 hasBestOaLocation W29387210572 @default.
- W2938721057 hasConcept C121608353 @default.
- W2938721057 hasConcept C126322002 @default.
- W2938721057 hasConcept C17991360 @default.
- W2938721057 hasConcept C203014093 @default.
- W2938721057 hasConcept C2776214593 @default.
- W2938721057 hasConcept C2776694085 @default.
- W2938721057 hasConcept C2776914184 @default.
- W2938721057 hasConcept C2777704314 @default.
- W2938721057 hasConcept C2779959927 @default.
- W2938721057 hasConcept C2780035454 @default.
- W2938721057 hasConcept C2781303535 @default.