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- W2938751402 abstract "<b>BACKGROUND:</b> Gait instability is one of the disabling clinical features of majority of patients suffering from Parkinson’s disease (PD). It is partially responsive to dopamine replacement therapy. Precise evaluation of distinct <sc>l</sc>-DOPA-sensitive and <sc>l</sc>-DOPA-resistant gait profiles might help in planning therapy of PD patients with gait disorder.<b>METHOD:</b> In this cross-sectional analytical study, we measured the gait parameters of 70 patients and 37 healthy participants using a 6.1-m long electronic walkway containing thousands of pressure sensors embedded in a carpet. The patients were evaluated in their OFF and ON phases of <sc>l</sc>-DOPA medication, and the data were compared with age- and gender-matched healthy controls.<b>RESULTS:</b> Except for the cadence, most gait parameters including velocity, stride length, and step length were deranged in PD patients. The mean velocity was significantly higher among healthy volunteers (99.19cm/s) compared to PD patients (73.90cm/s, <i>P</i> value 0.0001). However, the mean cadence was comparable between healthy and patient groups (103.29 vs. 103.39, <i>P</i> value 0.966). Certain temporal parameters (cadence, cycle time, and swing time) were nonresponsive to the dopaminergic therapy.<b>CONCLUSION:</b> On the basis of the findings, we propose that <sc>l</sc>-DOPA treatment improves most of the spatiotemporal gait parameters but cannot completely eliminate the risk of fall." @default.
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- W2938751402 date "2019-01-01" @default.
- W2938751402 modified "2023-10-18" @default.
- W2938751402 title "Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA" @default.
- W2938751402 doi "https://doi.org/10.4103/aomd.aomd_19_18" @default.
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