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- W2938751496 endingPage "e01405" @default.
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- W2938751496 abstract "In this study, we analyzed the capability of unmodified β-cyclodextrin (β-CD) to form the stable complex with serotonin hydrochloride (SER), as an important neurotransmitter in the brain. The stable β-CD: SER formulation was prepared and characterized using spectroscopic, thermal, molecular docking, and molecular dynamics techniques, revealing the phenomenon of H-bond formations and the domination of hydrophobic forces between the host molecule and its guest via the amine group of SER and the narrow side of β-CD. The complexation mechanism was mainly enthalpy-driven, representing the improvement in SER photo-stability. Overall, the results highlighted the possibility to use this formulation with improved stability in clinical practice for treatment and prevention of various depressive conditions, such as anxiety disorders." @default.
- W2938751496 created "2019-04-25" @default.
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- W2938751496 date "2019-04-01" @default.
- W2938751496 modified "2023-10-16" @default.
- W2938751496 title "Detailed chemical characterization and molecular modeling of serotonin inclusion complex with unmodified β-cyclodextrin" @default.
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- W2938751496 doi "https://doi.org/10.1016/j.heliyon.2019.e01405" @default.
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