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• W2938753846 endingPage "1839" @default.
• W2938753846 startingPage "1839" @default.
• W2938753846 abstract "Myeloproliferative neoplasms represent a heterogenous group of disorders of the hematopoietic stem cell, with an intrinsic risk of evolution into acute myeloid leukemia. The frequency of leukemic evolution varies according to myeloproliferative neoplasms subtype. It is highest in primary myelofibrosis, where it is estimated to be approximately 10–20% at 10 years, following by polycythemia vera, with a risk of 2.3% at 10 years and 7.9% at 20 years. In essential thrombocythemia, however, transformation to acute myeloid leukemia is considered relatively uncommon. Different factors are associated with leukemic evolution in myeloproliferative neoplasms, but generally include advanced age, leukocytosis, exposure to myelosuppressive therapy, cytogenetic abnormalities, as well as increased number of mutations in genes associated with myeloid neoplasms. The prognosis of these patients is dismal, with a medium overall survival ranging from 2.6–7.0 months. Currently, there is no standard of care for managing the blast phase of these diseases, and no treatment to date has consistently led to prolonged survival and/or hematological remission apart from an allogeneic stem cell transplant. Nevertheless, new targeted agents are currently under development. In this review, we present the current evidence regarding risk factors, molecular characterization, and treatment options for this critical subset of myeloproliferative neoplasms patients." @default.
• W2938753846 created "2019-04-25" @default.
• W2938753846 creator A5006810419 @default.
• W2938753846 creator A5054957586 @default.
• W2938753846 creator A5087305075 @default.
• W2938753846 date "2019-04-13" @default.
• W2938753846 modified "2023-10-16" @default.
• W2938753846 title "Blast Transformation in Myeloproliferative Neoplasms: Risk Factors, Biological Findings, and Targeted Therapeutic Options" @default.
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• W2938753846 doi "https://doi.org/10.3390/ijms20081839" @default.
• W2938753846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6514804" @default.
• W2938753846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31013941" @default.
• W2938753846 hasPublicationYear "2019" @default.
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