Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938776793> ?p ?o ?g. }
- W2938776793 abstract "Abstract Antitumor activity of triterpenoid and its derivatives has attracted great attention recently. Our previous efforts led to the discovery of a series of NO‐donor betulin derivatives with potent antitumor activity. Herein, we prepared eight compounds derived from ursolic acid (UA). All the compounds were evaluated for their in vitro cytotoxicity against four human cancer cell lines (HepG‐2, MCF‐7, HT‐29 and A549). Among the compounds tested, compound 4a was found to be most active against HT‐29 (IC 50 =4.28 μ m ). Further biological assays demonstrated that compound 4a could induce cell cycle arrest at G1 phase and apoptosis in a dose‐dependent manner. In addition, compound 4a was found to upregulate pro‐apoptotic Bax, p53 and downregulate anti‐apoptotic Bcl‐2. All these results suggested that compound 4a is a potential candidate drug for the therapy of colon cancer." @default.
- W2938776793 created "2019-04-25" @default.
- W2938776793 creator A5001527974 @default.
- W2938776793 creator A5013132668 @default.
- W2938776793 creator A5036763100 @default.
- W2938776793 creator A5065187670 @default.
- W2938776793 creator A5069596466 @default.
- W2938776793 creator A5072936276 @default.
- W2938776793 creator A5084044454 @default.
- W2938776793 creator A5085142676 @default.
- W2938776793 creator A5090278363 @default.
- W2938776793 creator A5090606294 @default.
- W2938776793 date "2019-05-28" @default.
- W2938776793 modified "2023-10-06" @default.
- W2938776793 title "Synthesis and Antitumor Evaluation in Vitro of NO‐Donating Ursolic Acid‐Benzylidene Derivatives" @default.
- W2938776793 cites W1913371122 @default.
- W2938776793 cites W1962560230 @default.
- W2938776793 cites W1981242195 @default.
- W2938776793 cites W1992179114 @default.
- W2938776793 cites W1992185123 @default.
- W2938776793 cites W1993046616 @default.
- W2938776793 cites W2004336249 @default.
- W2938776793 cites W2038691107 @default.
- W2938776793 cites W2062587977 @default.
- W2938776793 cites W2063822371 @default.
- W2938776793 cites W2068693124 @default.
- W2938776793 cites W2068916815 @default.
- W2938776793 cites W2071988200 @default.
- W2938776793 cites W2092161899 @default.
- W2938776793 cites W2123151746 @default.
- W2938776793 cites W2138740823 @default.
- W2938776793 cites W2240093536 @default.
- W2938776793 cites W2285650663 @default.
- W2938776793 cites W2336071846 @default.
- W2938776793 cites W2394770785 @default.
- W2938776793 cites W2407745354 @default.
- W2938776793 cites W2419563413 @default.
- W2938776793 cites W2518797936 @default.
- W2938776793 cites W2560124827 @default.
- W2938776793 cites W2575618192 @default.
- W2938776793 cites W2596973274 @default.
- W2938776793 cites W2606419266 @default.
- W2938776793 cites W2606870705 @default.
- W2938776793 cites W2711258373 @default.
- W2938776793 cites W2727331926 @default.
- W2938776793 cites W2747534218 @default.
- W2938776793 cites W2765987708 @default.
- W2938776793 cites W2766441270 @default.
- W2938776793 cites W2772095112 @default.
- W2938776793 cites W2783893447 @default.
- W2938776793 cites W2791051388 @default.
- W2938776793 doi "https://doi.org/10.1002/cbdv.201900111" @default.
- W2938776793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30977577" @default.
- W2938776793 hasPublicationYear "2019" @default.
- W2938776793 type Work @default.
- W2938776793 sameAs 2938776793 @default.
- W2938776793 citedByCount "6" @default.
- W2938776793 countsByYear W29387767932020 @default.
- W2938776793 countsByYear W29387767932021 @default.
- W2938776793 countsByYear W29387767932022 @default.
- W2938776793 countsByYear W29387767932023 @default.
- W2938776793 crossrefType "journal-article" @default.
- W2938776793 hasAuthorship W2938776793A5001527974 @default.
- W2938776793 hasAuthorship W2938776793A5013132668 @default.
- W2938776793 hasAuthorship W2938776793A5036763100 @default.
- W2938776793 hasAuthorship W2938776793A5065187670 @default.
- W2938776793 hasAuthorship W2938776793A5069596466 @default.
- W2938776793 hasAuthorship W2938776793A5072936276 @default.
- W2938776793 hasAuthorship W2938776793A5084044454 @default.
- W2938776793 hasAuthorship W2938776793A5085142676 @default.
- W2938776793 hasAuthorship W2938776793A5090278363 @default.
- W2938776793 hasAuthorship W2938776793A5090606294 @default.
- W2938776793 hasConcept C104317684 @default.
- W2938776793 hasConcept C105696609 @default.
- W2938776793 hasConcept C109316439 @default.
- W2938776793 hasConcept C127561419 @default.
- W2938776793 hasConcept C185592680 @default.
- W2938776793 hasConcept C190283241 @default.
- W2938776793 hasConcept C202751555 @default.
- W2938776793 hasConcept C21951064 @default.
- W2938776793 hasConcept C2778509883 @default.
- W2938776793 hasConcept C2779513101 @default.
- W2938776793 hasConcept C29537977 @default.
- W2938776793 hasConcept C43617362 @default.
- W2938776793 hasConcept C54355233 @default.
- W2938776793 hasConcept C55493867 @default.
- W2938776793 hasConcept C71240020 @default.
- W2938776793 hasConcept C81885089 @default.
- W2938776793 hasConcept C86803240 @default.
- W2938776793 hasConcept C98274493 @default.
- W2938776793 hasConceptScore W2938776793C104317684 @default.
- W2938776793 hasConceptScore W2938776793C105696609 @default.
- W2938776793 hasConceptScore W2938776793C109316439 @default.
- W2938776793 hasConceptScore W2938776793C127561419 @default.
- W2938776793 hasConceptScore W2938776793C185592680 @default.
- W2938776793 hasConceptScore W2938776793C190283241 @default.
- W2938776793 hasConceptScore W2938776793C202751555 @default.
- W2938776793 hasConceptScore W2938776793C21951064 @default.
- W2938776793 hasConceptScore W2938776793C2778509883 @default.
- W2938776793 hasConceptScore W2938776793C2779513101 @default.