FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938784753> ?p ?o ?g. }

• W2938784753 abstract "Abstract Aims Antihypertensive drugs are included in the medical therapy of vascular Ehlers–Danlos syndrome (vEDS). The β-blocker celiprolol has been suggested to prevent arterial damage in vEDS, but the underlying mechanism remains unclear. It is also unknown whether the widely used angiotensin II receptor type 1 antagonist losartan has a therapeutic effect in vEDS. Here, we evaluated the impact of celiprolol and losartan on the biomechanical integrity of the vEDS thoracic aorta. Methods and results We established a new approach to measure the maximum tensile force at rupture of uniaxially stretched murine thoracic aortic rings. In a vEDS model, which we (re-)characterized here at molecular level, heterozygous mice showed a significant reduction in the rupture force compared to wild-type mice, reflecting the increased mortality due to aortic rupture. For the assessment of treatment effects, heterozygous mice at 4 weeks of age underwent a 4-week treatment with celiprolol, losartan, and, as a proof-of-concept drug, the matrix metalloproteinase inhibitor doxycycline. Compared to age- and sex-matched untreated heterozygous mice, treatment with doxycycline or celiprolol resulted in a significant increase of rupture force, whereas no significant change was detected upon losartan treatment. Conclusions In a vEDS model, celiprolol or doxycycline, but not losartan, can improve the biomechanical integrity of the aortic wall, thereby potentially reducing the risk of dissection and rupture. As doxycycline is a broad-spectrum antibiotic with considerable side effects, celiprolol may be more suitable for a long-term therapy and thus rather indicated for the medication of patients with vEDS." @default.
• W2938784753 created "2019-04-25" @default.
• W2938784753 creator A5011309110 @default.
• W2938784753 creator A5014714790 @default.
• W2938784753 creator A5021939346 @default.
• W2938784753 creator A5024151397 @default.
• W2938784753 creator A5024974437 @default.
• W2938784753 creator A5036064021 @default.
• W2938784753 creator A5037473371 @default.
• W2938784753 creator A5043166775 @default.
• W2938784753 creator A5049651550 @default.
• W2938784753 creator A5069818774 @default.
• W2938784753 creator A5071253228 @default.
• W2938784753 creator A5073434598 @default.
• W2938784753 creator A5075891829 @default.
• W2938784753 creator A5080831392 @default.
• W2938784753 date "2019-04-08" @default.
• W2938784753 modified "2023-10-17" @default.
• W2938784753 title "Celiprolol but not losartan improves the biomechanical integrity of the aorta in a mouse model of vascular Ehlers–Danlos syndrome" @default.
• W2938784753 cites W1483015270 @default.
• W2938784753 cites W1557878150 @default.
• W2938784753 cites W1984138395 @default.
• W2938784753 cites W1992281996 @default.
• W2938784753 cites W2016256135 @default.
• W2938784753 cites W2019823018 @default.
• W2938784753 cites W2027819276 @default.
• W2938784753 cites W2030018298 @default.
• W2938784753 cites W2037981977 @default.
• W2938784753 cites W2038528879 @default.
• W2938784753 cites W2049635464 @default.
• W2938784753 cites W2055447043 @default.
• W2938784753 cites W2065215198 @default.
• W2938784753 cites W2069881257 @default.
• W2938784753 cites W2071536276 @default.
• W2938784753 cites W2075631279 @default.
• W2938784753 cites W2079513038 @default.
• W2938784753 cites W2079738970 @default.
• W2938784753 cites W2101780360 @default.
• W2938784753 cites W2107565203 @default.
• W2938784753 cites W2108271440 @default.
• W2938784753 cites W2114815932 @default.
• W2938784753 cites W2131079567 @default.
• W2938784753 cites W2134642866 @default.
• W2938784753 cites W2145897785 @default.
• W2938784753 cites W2148327933 @default.
• W2938784753 cites W2152350731 @default.
• W2938784753 cites W2153707891 @default.
• W2938784753 cites W2157097435 @default.
• W2938784753 cites W2290466312 @default.
• W2938784753 cites W2346049830 @default.
• W2938784753 cites W2467551987 @default.
• W2938784753 cites W2580979550 @default.
• W2938784753 cites W2603213486 @default.
• W2938784753 cites W2616926463 @default.
• W2938784753 cites W2785896838 @default.
• W2938784753 cites W2793754317 @default.
• W2938784753 cites W4214910844 @default.
• W2938784753 doi "https://doi.org/10.1093/cvr/cvz095" @default.
• W2938784753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31056650" @default.
• W2938784753 hasPublicationYear "2019" @default.
• W2938784753 type Work @default.
• W2938784753 sameAs 2938784753 @default.
• W2938784753 citedByCount "12" @default.
• W2938784753 countsByYear W29387847532019 @default.
• W2938784753 countsByYear W29387847532020 @default.
• W2938784753 countsByYear W29387847532021 @default.
• W2938784753 countsByYear W29387847532022 @default.
• W2938784753 countsByYear W29387847532023 @default.
• W2938784753 crossrefType "journal-article" @default.
• W2938784753 hasAuthorship W2938784753A5011309110 @default.
• W2938784753 hasAuthorship W2938784753A5014714790 @default.
• W2938784753 hasAuthorship W2938784753A5021939346 @default.
• W2938784753 hasAuthorship W2938784753A5024151397 @default.
• W2938784753 hasAuthorship W2938784753A5024974437 @default.
• W2938784753 hasAuthorship W2938784753A5036064021 @default.
• W2938784753 hasAuthorship W2938784753A5037473371 @default.
• W2938784753 hasAuthorship W2938784753A5043166775 @default.
• W2938784753 hasAuthorship W2938784753A5049651550 @default.
• W2938784753 hasAuthorship W2938784753A5069818774 @default.
• W2938784753 hasAuthorship W2938784753A5071253228 @default.
• W2938784753 hasAuthorship W2938784753A5073434598 @default.
• W2938784753 hasAuthorship W2938784753A5075891829 @default.
• W2938784753 hasAuthorship W2938784753A5080831392 @default.
• W2938784753 hasBestOaLocation W29387847531 @default.
• W2938784753 hasConcept C126322002 @default.
• W2938784753 hasConcept C141071460 @default.
• W2938784753 hasConcept C164705383 @default.
• W2938784753 hasConcept C170493617 @default.
• W2938784753 hasConcept C185592680 @default.
• W2938784753 hasConcept C2777179404 @default.
• W2938784753 hasConcept C2777953023 @default.
• W2938784753 hasConcept C2778333328 @default.
• W2938784753 hasConcept C2778994441 @default.
• W2938784753 hasConcept C2779980429 @default.
• W2938784753 hasConcept C2780288358 @default.
• W2938784753 hasConcept C2908929049 @default.
• W2938784753 hasConcept C501593827 @default.
• W2938784753 hasConcept C55493867 @default.
• W2938784753 hasConcept C71924100 @default.
• W2938784753 hasConcept C84393581 @default.

• next