Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938803199> ?p ?o ?g. }
- W2938803199 abstract "Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying physics or biological pathways. To demonstrate ML-guided directed evolution, we introduce the steps required to build ML sequence-function models and use them to guide engineering, making recommendations at each stage. This review covers basic concepts relevant to using ML for protein engineering as well as the current literature and applications of this new engineering paradigm. ML methods accelerate directed evolution by learning from information contained in all measured variants and using that information to select sequences that are likely to be improved. We then provide two case studies that demonstrate the ML-guided directed evolution process. We also look to future opportunities where ML will enable discovery of new protein functions and uncover the relationship between protein sequence and function." @default.
- W2938803199 created "2019-04-25" @default.
- W2938803199 creator A5003064960 @default.
- W2938803199 creator A5033526989 @default.
- W2938803199 creator A5060834723 @default.
- W2938803199 date "2018-11-27" @default.
- W2938803199 modified "2023-09-27" @default.
- W2938803199 title "Machine learning-guided directed evolution for protein engineering" @default.
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