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- W2938816722 abstract "Psoriasis is a chronic inflammatory skin condition whose severity has been linked with obesity. In patients with psoriasis, the likelihood of developing new-onset obesity is higher than those without psoriasis. Stearoyl-CoA desaturase (SCD), is an endoplasmic reticulum resident desaturase, that acts as a catalyst in the synthesis of monounsaturated fatty acids. Mice lacking SCD1 are insulin sensitive, resistant to development of obesity and exhibit suppressed fatty acid synthesis. We have earlier shown that skin specific deletion of SCD1 in mice (SKO) results in epidermal proliferation, sebaceous gland hypoplasia and elevated interleukin 6 levels. We hypothesized that SCD1 deficiency will render mice susceptible to imiquimod (IMQ)-induced psoriasiform dermatitis. A topical dose of 62.5 mg IMQ cream was applied daily to the shaved back region of SKO and SCD1 proficient FLOX counterparts for 14 days after which the mice were euthanized. Cumulative average skin thickness in SKO animals following IMQ application, measured prior to excision was significantly (36%) less than that in FLOX animals. Quantitation of epidermal thickness in H&E stained skin sections validated this observation. Further, histological analysis revealed that in spite of skin inflammation and hair follicle dysplasia associated with their genetic background, the degree of IMQ associated inflammatory changes in the SKO mice were remarkably less than that in FLOX counterparts. Keratin 14, the prototypic marker of dividing basal keratinocytes was elevated in IMQ-treated FLOX skin. Moreover, fatty acid binding protein 5, upregulated in psoriasis tissue was reduced in SKO skin. Our data suggests a complex relationship between fatty acid metabolism and cytoskeletal proteins driving aberrant cell proliferation in psoriatic skin. We propose that SCD1 inhibition could be a novel approach for the management of psoriasis, especially in obese individuals." @default.
- W2938816722 created "2019-04-25" @default.
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- W2938816722 date "2019-05-01" @default.
- W2938816722 modified "2023-09-29" @default.
- W2938816722 title "656 Psoriasis and obesity: Stearoyl-CoA desaturase 1 deficient mice are resistant to imiquimod-induced psoriasiform dermatitis" @default.
- W2938816722 doi "https://doi.org/10.1016/j.jid.2019.03.732" @default.
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