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- W2938820758 abstract "Abstract Negative symptoms are recognized as a fundamental feature of schizophrenia throughout the disease course. Epigenetic alterations in the oxytocin receptor gene (OXTR) may be a key mechanism involved in social-emotional disturbances of schizophrenia. Here, we investigated OXTR methylation and its association with clinical and brain network connectivity phenotypes of negative symptoms, particularly anhedonia-asociality, in individuals with recent-onset schizophrenia (ROS) and at ultrahigh risk (UHR) for psychosis. Sixty-four ROS (39 women), 46 UHR (19 women), and 98 healthy individuals (52 women) participated in this study. OXTR methylation was quantified using the pyrosequencing method. A subset of participants (16 ROS, 23 UHR, and 33 healthy controls [HCs]) underwent a 5.5-minute resting-state functional magnetic resonance imaging to determine the relationship between OXTR methylation and the striatal-amygdala network functional connectivity (FC) underlying anhedonia-asociality. Both men and women with ROS and UHR showed significantly decreased OXTR methylation compared to HCs. In women with ROS and UHR, decreased OXTR methylation showed a significant correlation with increased anhedonia-asociality. FC of the striatal-amygdala network, positively associated with the severity of anhedonia-asociality, showed an inverse correlation with OXTR methylation. This study suggests that epigenetic alterations of OXTR, which can be detected before the development of full-blown psychosis, confer susceptibility to schizophrenia and play a crucial role in the manifestation of anhedonia-asociality, particularly in women." @default.
- W2938820758 created "2019-04-25" @default.
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- W2938820758 date "2019-04-09" @default.
- W2938820758 modified "2023-10-16" @default.
- W2938820758 title "Reduced DNA Methylation of the Oxytocin Receptor Gene Is Associated With Anhedonia-Asociality in Women With Recent-Onset Schizophrenia and Ultra-high Risk for Psychosis" @default.
- W2938820758 cites W1067107096 @default.
- W2938820758 cites W1441608289 @default.
- W2938820758 cites W1556392272 @default.
- W2938820758 cites W1939311028 @default.
- W2938820758 cites W1967064280 @default.
- W2938820758 cites W1975008822 @default.
- W2938820758 cites W1976289354 @default.
- W2938820758 cites W1983183519 @default.
- W2938820758 cites W1985327120 @default.
- W2938820758 cites W1994025579 @default.
- W2938820758 cites W1998913705 @default.
- W2938820758 cites W1999436824 @default.
- W2938820758 cites W2007651260 @default.
- W2938820758 cites W2013814152 @default.
- W2938820758 cites W2019416640 @default.
- W2938820758 cites W2023636464 @default.
- W2938820758 cites W2033955495 @default.
- W2938820758 cites W2039406801 @default.
- W2938820758 cites W2039714243 @default.
- W2938820758 cites W2042669554 @default.
- W2938820758 cites W2046053576 @default.
- W2938820758 cites W2051330882 @default.
- W2938820758 cites W2056492865 @default.
- W2938820758 cites W2059917192 @default.
- W2938820758 cites W2061325549 @default.
- W2938820758 cites W2068677067 @default.
- W2938820758 cites W2068772097 @default.
- W2938820758 cites W2074783654 @default.
- W2938820758 cites W2074914062 @default.
- W2938820758 cites W2078940490 @default.
- W2938820758 cites W2082207932 @default.
- W2938820758 cites W2083000419 @default.
- W2938820758 cites W2084053184 @default.
- W2938820758 cites W2084331056 @default.
- W2938820758 cites W2090852431 @default.
- W2938820758 cites W2091864947 @default.
- W2938820758 cites W2093553894 @default.
- W2938820758 cites W2095144882 @default.
- W2938820758 cites W2102308037 @default.
- W2938820758 cites W2104111165 @default.
- W2938820758 cites W2104323563 @default.
- W2938820758 cites W2110565828 @default.
- W2938820758 cites W2114229031 @default.
- W2938820758 cites W2117633779 @default.
- W2938820758 cites W2122556992 @default.
- W2938820758 cites W2123137331 @default.
- W2938820758 cites W2124757386 @default.
- W2938820758 cites W2126092973 @default.
- W2938820758 cites W2126398688 @default.
- W2938820758 cites W2128784178 @default.
- W2938820758 cites W2132152083 @default.
- W2938820758 cites W2135120423 @default.
- W2938820758 cites W2140824803 @default.
- W2938820758 cites W2145850516 @default.
- W2938820758 cites W2146204021 @default.
- W2938820758 cites W2152965653 @default.
- W2938820758 cites W2153254138 @default.
- W2938820758 cites W2155020127 @default.
- W2938820758 cites W2156869908 @default.
- W2938820758 cites W2159963071 @default.
- W2938820758 cites W2162421104 @default.
- W2938820758 cites W2164597099 @default.
- W2938820758 cites W2165988750 @default.
- W2938820758 cites W2170681314 @default.
- W2938820758 cites W2176365174 @default.
- W2938820758 cites W2198794209 @default.
- W2938820758 cites W2298685505 @default.
- W2938820758 cites W2468956824 @default.
- W2938820758 cites W2605494294 @default.
- W2938820758 cites W2793284717 @default.
- W2938820758 cites W318497691 @default.
- W2938820758 cites W4231029336 @default.
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- W2938820758 doi "https://doi.org/10.1093/schbul/sbz016" @default.
- W2938820758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6812051" @default.
- W2938820758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31220321" @default.
- W2938820758 hasPublicationYear "2019" @default.
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