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- W2938821504 endingPage "5188" @default.
- W2938821504 startingPage "5175" @default.
- W2938821504 abstract "Systemic Lupus Erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from clinical application, further investigation of environmental risk factors could reveal important therapeutic approaches. We systematically explored two groups of environmental risk factors: chemicals (including silica, solvents, pesticides, hydrocarbons, heavy metals, and particulate matter) and drugs (including procainamide, hydralazine, quinidine, Dpenicillamine, isoniazid, and methyldopa). Furthermore, the mechanisms underlying risk factors, such as genetic factors, epigenetic change, and disrupted immune tolerance, were explored. This review identifies novel risk factors and their underlying mechanisms. Practicable measures for the management of these risk factors will benefit SLE patients and provide potential therapeutic strategies." @default.
- W2938821504 created "2019-04-25" @default.
- W2938821504 creator A5005368416 @default.
- W2938821504 creator A5033765430 @default.
- W2938821504 creator A5051217962 @default.
- W2938821504 creator A5055372987 @default.
- W2938821504 creator A5055814467 @default.
- W2938821504 creator A5061764811 @default.
- W2938821504 creator A5089630300 @default.
- W2938821504 date "2020-09-11" @default.
- W2938821504 modified "2023-10-05" @default.
- W2938821504 title "Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus" @default.
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