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• W2938835543 abstract "Diabetes mellitus (DM) is considered the epidemic of the 21st century. Traditional medicine uses plants to treat DM; many of these have hypoglycemic effects in both animal models and diabetic patients. Our objective was to evaluate the hypoglycemic activity of Tilia americana , Borago officinalis , Chenopodium nuttalliae , and Piper sanctum on diabetic rats. The methanolic extracts of the plants under study were obtained by Soxhlet extraction. Toxicity was evaluated on Artemia salina ; the antioxidant potential was evaluated using the DPPH technique. Hypoglycemic capacity at doses of 250 and 500 mg/kg was tested on Wistar rats with diabetes induced by alloxan (120 mg/kg). The toxicity on A. salina was null for the extracts of B. officinalis and P. sanctum , moderate for T. americana , and highly toxic for C. nuttalliae . The relevant extract of T. americana var. mexicana showed antioxidant activity. Three plants of the studied plants showed hypoglycemic activity: Tilia Americana (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0142</mml:mn></mml:math>), Borago officinalis (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0112</mml:mn></mml:math>), and Piper sanctum (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0078</mml:mn></mml:math>); P. sanctum was the one that showed the greatest reduction in glucose levels at a lower dose." @default.
• W2938835543 created "2019-04-25" @default.
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• W2938835543 date "2019-04-16" @default.
• W2938835543 modified "2023-10-16" @default.
• W2938835543 title "Hypoglycemic Activity of<i>Tilia americana</i>,<i>Borago officinalis</i>,<i>Chenopodium nuttalliae</i>, and<i>Piper sanctum</i>on Wistar Rats" @default.
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• W2938835543 doi "https://doi.org/10.1155/2019/7836820" @default.
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