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- W2938846115 abstract "Stroke, a leading cause of long-term disability and death worldwide, has a heritable component. Recent gene discovery efforts have expanded the number of known single-gene disorders associated with stroke and have linked common variants at approximately 35 genetic loci to stroke risk. These discoveries have highlighted novel mechanisms and pathways implicated in stroke related to large artery atherosclerosis, cardioembolism, and small vessel disease, and defined shared genetic influences with related vascular traits. Genetics has also successfully established causal relationships with risk factors and holds promise for prioritising targets for exploration in clinical trials. Genome-wide polygenic scores enable the identification of high-risk individuals before the emergence of vascular risk factors. Challenges ahead include a better understanding of rare variants and ancestral differences for integration of genetics into precision medicine, integration with other omics data, uncovering the genetic factors that govern stroke recurrence and stroke outcome, and the conversion of genetic discoveries to novel therapies." @default.
- W2938846115 created "2019-04-25" @default.
- W2938846115 creator A5006664647 @default.
- W2938846115 creator A5061123357 @default.
- W2938846115 creator A5085706431 @default.
- W2938846115 date "2019-06-01" @default.
- W2938846115 modified "2023-09-29" @default.
- W2938846115 title "Stroke genetics: discovery, biology, and clinical applications" @default.
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