FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938851179> ?p ?o ?g. }

• W2938851179 endingPage "354" @default.
• W2938851179 startingPage "341" @default.
• W2938851179 abstract "Objective: This study was aimed to evaluate the effect of tannic acid (TA), a natural plant polyphenol astringent, on wound healing in vitro and in vivo, and to elucidate the underlying molecular signaling pathway in the wound healing. Approach: Cutaneous skin wounds were created in rats and then treated until closure with purified TA, serum or tissue samples were collected to test the concentration of factors by enzyme-linked immunosorbent assay (ELISA), and the expression in gene or protein was measured by quantitative real-time polymerase chain reaction or Western blot. We explored the cell-/dose-specific responses of TA (0.1-0.4 μg/mL) on proliferation and gene and protein expression of fibroblast NIH 3T3 cells. Results: The wounds on rats treated by TA got healed faster than those in the untreated group. The histopathology study showed that TA accelerated re-epithelialization and increase in hair follicles could be detected. The levels of growth factors including basic fibroblast growth factor (bFGF), transforming growth factor-beta, and vascular endothelial growth factor in TA-treated groups were all increased, and the content of interleukin-1 (IL-1) and IL-6 was decreased significantly when compared with that of the untreated group. The NIH 3T3 cells grow faster in 6 h at concentration of 0.1 μg/mL, and the expression of bFGF in gene and protein was increased significantly in the 0.1 μg/mL TA group. Further study revealed that the protein levels of bFGF, extracellular signal regulated kinase (Erk) 1/2, and P-Erk 1/2 in Erk 1/2 pathway were increased after TA treatment. Innovation: The role of TA in wound healing efficacy is unclear; this study, therefore, assesses the effects of TA on wound healing in different periods and the underlying molecular mechanisms. Conclusion: These results suggested that TA could accelerate wound healing through modulation of inflammatory cytokines and growth factors and activate Erk 1/2 pathway. In conclusion, TA may be a potential agent in promoting wound healing." @default.
• W2938851179 created "2019-04-25" @default.
• W2938851179 creator A5006180838 @default.
• W2938851179 creator A5006485053 @default.
• W2938851179 creator A5019444758 @default.
• W2938851179 creator A5037336737 @default.
• W2938851179 creator A5057911611 @default.
• W2938851179 creator A5058454291 @default.
• W2938851179 creator A5060667009 @default.
• W2938851179 creator A5064308879 @default.
• W2938851179 creator A5064813580 @default.
• W2938851179 creator A5070356958 @default.
• W2938851179 creator A5079506586 @default.
• W2938851179 creator A5081884581 @default.
• W2938851179 creator A5083292183 @default.
• W2938851179 date "2019-07-01" @default.
• W2938851179 modified "2023-10-16" @default.
• W2938851179 title "Tannic Acid Accelerates Cutaneous Wound Healing in Rats Via Activation of the <i>ERK 1/2</i> Signaling Pathways" @default.
• W2938851179 cites W1931315964 @default.
• W2938851179 cites W1949832432 @default.
• W2938851179 cites W1954102409 @default.
• W2938851179 cites W1975548084 @default.
• W2938851179 cites W2006812373 @default.
• W2938851179 cites W2011751753 @default.
• W2938851179 cites W2020141624 @default.
• W2938851179 cites W2023644659 @default.
• W2938851179 cites W2045713552 @default.
• W2938851179 cites W2047566406 @default.
• W2938851179 cites W2050248964 @default.
• W2938851179 cites W2050867650 @default.
• W2938851179 cites W2107495112 @default.
• W2938851179 cites W2161146123 @default.
• W2938851179 cites W2162599629 @default.
• W2938851179 cites W2404013489 @default.
• W2938851179 cites W2506444115 @default.
• W2938851179 cites W2547708096 @default.
• W2938851179 cites W2564769225 @default.
• W2938851179 cites W2767466184 @default.
• W2938851179 cites W2774122660 @default.
• W2938851179 cites W2793177982 @default.
• W2938851179 doi "https://doi.org/10.1089/wound.2018.0853" @default.
• W2938851179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6855284" @default.
• W2938851179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31737421" @default.
• W2938851179 hasPublicationYear "2019" @default.
• W2938851179 type Work @default.
• W2938851179 sameAs 2938851179 @default.
• W2938851179 citedByCount "28" @default.
• W2938851179 countsByYear W29388511792019 @default.
• W2938851179 countsByYear W29388511792020 @default.
• W2938851179 countsByYear W29388511792021 @default.
• W2938851179 countsByYear W29388511792022 @default.
• W2938851179 countsByYear W29388511792023 @default.
• W2938851179 crossrefType "journal-article" @default.
• W2938851179 hasAuthorship W2938851179A5006180838 @default.
• W2938851179 hasAuthorship W2938851179A5006485053 @default.
• W2938851179 hasAuthorship W2938851179A5019444758 @default.
• W2938851179 hasAuthorship W2938851179A5037336737 @default.
• W2938851179 hasAuthorship W2938851179A5057911611 @default.
• W2938851179 hasAuthorship W2938851179A5058454291 @default.
• W2938851179 hasAuthorship W2938851179A5060667009 @default.
• W2938851179 hasAuthorship W2938851179A5064308879 @default.
• W2938851179 hasAuthorship W2938851179A5064813580 @default.
• W2938851179 hasAuthorship W2938851179A5070356958 @default.
• W2938851179 hasAuthorship W2938851179A5079506586 @default.
• W2938851179 hasAuthorship W2938851179A5081884581 @default.
• W2938851179 hasAuthorship W2938851179A5083292183 @default.
• W2938851179 hasBestOaLocation W29388511792 @default.
• W2938851179 hasConcept C104317684 @default.
• W2938851179 hasConcept C126322002 @default.
• W2938851179 hasConcept C150903083 @default.
• W2938851179 hasConcept C153911025 @default.
• W2938851179 hasConcept C16685009 @default.
• W2938851179 hasConcept C167734588 @default.
• W2938851179 hasConcept C170493617 @default.
• W2938851179 hasConcept C178790620 @default.
• W2938851179 hasConcept C184235292 @default.
• W2938851179 hasConcept C185592680 @default.
• W2938851179 hasConcept C202751555 @default.
• W2938851179 hasConcept C203014093 @default.
• W2938851179 hasConcept C207001950 @default.
• W2938851179 hasConcept C2775960820 @default.
• W2938851179 hasConcept C2776415932 @default.
• W2938851179 hasConcept C2777025900 @default.
• W2938851179 hasConcept C2777587049 @default.
• W2938851179 hasConcept C2780269544 @default.
• W2938851179 hasConcept C2780381497 @default.
• W2938851179 hasConcept C2781393965 @default.
• W2938851179 hasConcept C55493867 @default.
• W2938851179 hasConcept C57074206 @default.
• W2938851179 hasConcept C62478195 @default.
• W2938851179 hasConcept C71924100 @default.
• W2938851179 hasConcept C74373430 @default.
• W2938851179 hasConcept C86803240 @default.
• W2938851179 hasConceptScore W2938851179C104317684 @default.
• W2938851179 hasConceptScore W2938851179C126322002 @default.
• W2938851179 hasConceptScore W2938851179C150903083 @default.
• W2938851179 hasConceptScore W2938851179C153911025 @default.
• W2938851179 hasConceptScore W2938851179C16685009 @default.

• next