Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938860032> ?p ?o ?g. }
- W2938860032 abstract "Human placenta development and a successful pregnancy is incumbent upon precise oxygen-dependent control of trophoblast migration/invasion. Persistent low oxygen leading to failed trophoblast invasion promotes inadequate spiral artery remodeling, a characteristic of preeclampsia. Angiomotin (AMOT) is a multifaceted scaffolding protein involved in cell polarity and migration, yet its upstream regulation and significance in the human placenta remain unknown. Herein, we show that AMOT is primarily expressed in migratory extravillous trophoblast cells (EVTs) of the intermediate and distal anchoring column. Its expression increases after 10 weeks of gestation when oxygen tension rises and EVT migration/invasion peaks. Time-lapse imaging confirmed that the AMOT 80-kDa isoform promotes migration of trophoblastic JEG3 and HTR-8/SVneo cells. In preeclampsia, however, AMOT expression is decreased and its localization to migratory fetomaternal interface EVTs is disrupted. We demonstrate that Jumonji C domain-containing protein 6 (JMJD6), an oxygen sensor, positively regulates AMOT via oxygen-dependent lysyl hydroxylation. Furthermore, in vitro and ex vivo studies show that transforming growth factor-β (TGF-β) regulates AMOT expression, its interaction with polarity protein PAR6, and its subcellular redistribution from tight junctions to cytoskeleton. Our data reveal an oxygen- and TGF-β-driven migratory function for AMOT in the human placenta, and implicate its deficiency in impaired trophoblast migration that plagues preeclampsia." @default.
- W2938860032 created "2019-04-25" @default.
- W2938860032 creator A5012678845 @default.
- W2938860032 creator A5012815580 @default.
- W2938860032 creator A5038784021 @default.
- W2938860032 creator A5041078814 @default.
- W2938860032 creator A5058078956 @default.
- W2938860032 creator A5064120955 @default.
- W2938860032 creator A5066296455 @default.
- W2938860032 date "2019-04-18" @default.
- W2938860032 modified "2023-10-12" @default.
- W2938860032 title "Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia" @default.
- W2938860032 cites W1585598851 @default.
- W2938860032 cites W1597287151 @default.
- W2938860032 cites W1760215417 @default.
- W2938860032 cites W1783922739 @default.
- W2938860032 cites W1925213563 @default.
- W2938860032 cites W1972095962 @default.
- W2938860032 cites W1976474458 @default.
- W2938860032 cites W1982094164 @default.
- W2938860032 cites W1982260089 @default.
- W2938860032 cites W1996632350 @default.
- W2938860032 cites W2001910815 @default.
- W2938860032 cites W2006347607 @default.
- W2938860032 cites W2006612446 @default.
- W2938860032 cites W2010589579 @default.
- W2938860032 cites W2012463854 @default.
- W2938860032 cites W2013004928 @default.
- W2938860032 cites W2028919524 @default.
- W2938860032 cites W2031295435 @default.
- W2938860032 cites W2032665278 @default.
- W2938860032 cites W2034282698 @default.
- W2938860032 cites W2035984476 @default.
- W2938860032 cites W2036353137 @default.
- W2938860032 cites W2037807978 @default.
- W2938860032 cites W2038411007 @default.
- W2938860032 cites W2040435657 @default.
- W2938860032 cites W2050087753 @default.
- W2938860032 cites W2051627999 @default.
- W2938860032 cites W2053132501 @default.
- W2938860032 cites W2054079210 @default.
- W2938860032 cites W2058715094 @default.
- W2938860032 cites W2067621602 @default.
- W2938860032 cites W2068363048 @default.
- W2938860032 cites W2068978379 @default.
- W2938860032 cites W2072305777 @default.
- W2938860032 cites W2074546742 @default.
- W2938860032 cites W2081204899 @default.
- W2938860032 cites W2097321304 @default.
- W2938860032 cites W2102277066 @default.
- W2938860032 cites W2102625800 @default.
- W2938860032 cites W2103926981 @default.
- W2938860032 cites W2108260772 @default.
- W2938860032 cites W2117876140 @default.
- W2938860032 cites W2119084006 @default.
- W2938860032 cites W2120833719 @default.
- W2938860032 cites W2127347832 @default.
- W2938860032 cites W2130104786 @default.
- W2938860032 cites W2139202526 @default.
- W2938860032 cites W2143727653 @default.
- W2938860032 cites W2144378850 @default.
- W2938860032 cites W2148027060 @default.
- W2938860032 cites W2150967160 @default.
- W2938860032 cites W2164953175 @default.
- W2938860032 cites W2166938100 @default.
- W2938860032 cites W2167732604 @default.
- W2938860032 cites W2222577931 @default.
- W2938860032 cites W2254975421 @default.
- W2938860032 cites W2291913168 @default.
- W2938860032 cites W230744685 @default.
- W2938860032 cites W2417424288 @default.
- W2938860032 cites W2500524542 @default.
- W2938860032 cites W2584957827 @default.
- W2938860032 cites W2767989010 @default.
- W2938860032 cites W2775775321 @default.
- W2938860032 cites W2793857691 @default.
- W2938860032 cites W2793986089 @default.
- W2938860032 cites W301622561 @default.
- W2938860032 doi "https://doi.org/10.1172/jci.insight.127009" @default.
- W2938860032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6538363" @default.
- W2938860032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30996134" @default.
- W2938860032 hasPublicationYear "2019" @default.
- W2938860032 type Work @default.
- W2938860032 sameAs 2938860032 @default.
- W2938860032 citedByCount "25" @default.
- W2938860032 countsByYear W29388600322019 @default.
- W2938860032 countsByYear W29388600322020 @default.
- W2938860032 countsByYear W29388600322021 @default.
- W2938860032 countsByYear W29388600322022 @default.
- W2938860032 countsByYear W29388600322023 @default.
- W2938860032 crossrefType "journal-article" @default.
- W2938860032 hasAuthorship W2938860032A5012678845 @default.
- W2938860032 hasAuthorship W2938860032A5012815580 @default.
- W2938860032 hasAuthorship W2938860032A5038784021 @default.
- W2938860032 hasAuthorship W2938860032A5041078814 @default.
- W2938860032 hasAuthorship W2938860032A5058078956 @default.
- W2938860032 hasAuthorship W2938860032A5064120955 @default.
- W2938860032 hasAuthorship W2938860032A5066296455 @default.
- W2938860032 hasBestOaLocation W29388600321 @default.
- W2938860032 hasConcept C137738243 @default.