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- W2938862235 endingPage "e201900392" @default.
- W2938862235 startingPage "e201900392" @default.
- W2938862235 abstract "Aberrant mitochondrial dynamics disrupts mitochondrial function and contributes to disease conditions. A targeted RNA interference screen for deubiquitinating enzymes (DUBs) affecting protein levels of multifunctional mitochondrial fusion protein Mitofusin (MFN) identified USP8 prominently influencing MFN levels. Genetic and pharmacological inhibition of USP8 normalized the elevated MFN protein levels observed in PINK1 and Parkin-deficient models. This correlated with improved mitochondrial function, locomotor performance and life span, and prevented dopaminergic neurons loss in Drosophila PINK1 KO flies. We identified a novel target antagonizing pathologically elevated MFN levels, mitochondrial dysfunction, and dopaminergic neuron loss of a Drosophila model of mitochondrial dysfunction." @default.
- W2938862235 created "2019-04-25" @default.
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- W2938862235 date "2019-04-01" @default.
- W2938862235 modified "2023-09-30" @default.
- W2938862235 title "Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction" @default.
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