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• W2938898678 abstract "Objective: High-mobility group box 1 protein (HMGB1) is involved in the invasion and metastasis of a variety of tumor as a pro-inflammatory cytokines and growth factors. However, the role of HMGB1 in breast cancer remains to be clarified. In this study, we investigated the effect of exogenous HMGB1 on the malignant breast cancer cell proliferation, migration and invasion and explored possible mechanisms. Methods: We cultured MDA-MB-231 cells. MTT was used to monitor the cell proliferation. Transwell assay was used to assess migration and invasion of MDA-MB-231 cells. Western blotting and RT-PCR was employed to explore gene and protein expression. Results ： We found that HMGB1 promoted the proliferation of MDA-MB-231 cell. But this proliferation promoting effect does not show dose dependent. 400ng / ml rHMGB1 increased the migration cell number to 2.17 times (±0.21) ( P <0.05). Cell invasion test showed 400ng /ml HMGB1 increased the cell number of passing through the Matrigel to 2.58 times (±0.13) ( P <0.05). Further studies showed that HMGB1 significantly increased the expression of P65 in protein level, but not mRNA level and MMP9 expression mRNA and protein level. Conclusion: HMGB1 regulated the breast cancer cell behaviors. NF-κb signal way and MMP9 may contribute to it." @default.
• W2938898678 created "2019-04-25" @default.
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• W2938898678 date "2019-03-13" @default.
• W2938898678 modified "2023-09-23" @default.
• W2938898678 title "Exogenous HMGB1 promoted migration and invasion of breast cancer cells through NFκB and MMP9" @default.
• W2938898678 hasPublicationYear "2019" @default.
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