FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938930184> ?p ?o ?g. }

• W2938930184 endingPage "137" @default.
• W2938930184 startingPage "131" @default.
• W2938930184 abstract "Saikosaponin a (SSa), one of the major active components of Bupleurum falcatum, has antioxidant and anti-inflammatory pharmacological properties. However, the effects of SSa on liver injury have not been reported. In the present study, we evaluated the protective effects and mechanisms of SSa on lipopolysaccharide (LPS)/d‑galactosamine (D-GalN)-induced liver injury. The mice were pretreated with SSa 1 h before LPS/D-GalN treatment. The liver MPO, MDA, and the serum AST and ALT levels were tested by specific determination kits. The pro-inflammatory cytokines TNF-α and IL-1β were tested by ELISA kits. The expression of NF-κB signaling pathway and LXRα were tested by western blot analysis. The results showed that SSa significantly reduced the levels of liver MPO, MDA, and serum AST, ALT levels induced by LPS/D-GalN. SSa also dose-dependently inhibited LPS/D-GalN-induced pro-inflammatory cytokines TNF-α and IL-1β production. Furthermore, we found that SSa inhibited NF-κB signaling pathway activation induced by LPS/D-GalN. In addition, SSa dose-dependently increased the expression of LXRα. In conclusion, the results demonstrated that SSa had protective effect on liver injury and the anti-inflammatory mechanisms of SSa on LPS/D-GalN-induced liver injury may be due to its ability to increase LXRα expression. SSa might be a potential treatment for liver injury." @default.
• W2938930184 created "2019-04-25" @default.
• W2938930184 creator A5029398553 @default.
• W2938930184 creator A5045273219 @default.
• W2938930184 creator A5057605940 @default.
• W2938930184 creator A5078035930 @default.
• W2938930184 creator A5085375696 @default.
• W2938930184 date "2019-07-01" @default.
• W2938930184 modified "2023-10-02" @default.
• W2938930184 title "Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα" @default.
• W2938930184 cites W1511639797 @default.
• W2938930184 cites W1981956298 @default.
• W2938930184 cites W1986387288 @default.
• W2938930184 cites W1993012909 @default.
• W2938930184 cites W2013221039 @default.
• W2938930184 cites W2014227081 @default.
• W2938930184 cites W2026724662 @default.
• W2938930184 cites W2040233399 @default.
• W2938930184 cites W2043892945 @default.
• W2938930184 cites W2048960913 @default.
• W2938930184 cites W2049048694 @default.
• W2938930184 cites W2049923191 @default.
• W2938930184 cites W2059904244 @default.
• W2938930184 cites W2062913054 @default.
• W2938930184 cites W2065261900 @default.
• W2938930184 cites W2072447977 @default.
• W2938930184 cites W2109039477 @default.
• W2938930184 cites W2141962989 @default.
• W2938930184 cites W2163142501 @default.
• W2938930184 cites W2174763143 @default.
• W2938930184 cites W2260646036 @default.
• W2938930184 cites W2306164045 @default.
• W2938930184 cites W2339984771 @default.
• W2938930184 cites W2474737012 @default.
• W2938930184 cites W2495036841 @default.
• W2938930184 cites W2588442940 @default.
• W2938930184 cites W2594491387 @default.
• W2938930184 cites W2604924786 @default.
• W2938930184 cites W2605431070 @default.
• W2938930184 cites W2737566491 @default.
• W2938930184 cites W2746675146 @default.
• W2938930184 cites W2751015565 @default.
• W2938930184 cites W2762360150 @default.
• W2938930184 cites W2765282783 @default.
• W2938930184 cites W2795728319 @default.
• W2938930184 cites W2800321188 @default.
• W2938930184 cites W4240717991 @default.
• W2938930184 doi "https://doi.org/10.1016/j.intimp.2019.03.049" @default.
• W2938930184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30981078" @default.
• W2938930184 hasPublicationYear "2019" @default.
• W2938930184 type Work @default.
• W2938930184 sameAs 2938930184 @default.
• W2938930184 citedByCount "12" @default.
• W2938930184 countsByYear W29389301842019 @default.
• W2938930184 countsByYear W29389301842020 @default.
• W2938930184 countsByYear W29389301842021 @default.
• W2938930184 countsByYear W29389301842022 @default.
• W2938930184 countsByYear W29389301842023 @default.
• W2938930184 crossrefType "journal-article" @default.
• W2938930184 hasAuthorship W2938930184A5029398553 @default.
• W2938930184 hasAuthorship W2938930184A5045273219 @default.
• W2938930184 hasAuthorship W2938930184A5057605940 @default.
• W2938930184 hasAuthorship W2938930184A5078035930 @default.
• W2938930184 hasAuthorship W2938930184A5085375696 @default.
• W2938930184 hasConcept C104317684 @default.
• W2938930184 hasConcept C126322002 @default.
• W2938930184 hasConcept C134018914 @default.
• W2938930184 hasConcept C164027704 @default.
• W2938930184 hasConcept C185592680 @default.
• W2938930184 hasConcept C2776415932 @default.
• W2938930184 hasConcept C2776637226 @default.
• W2938930184 hasConcept C2776914184 @default.
• W2938930184 hasConcept C2778125326 @default.
• W2938930184 hasConcept C2778754761 @default.
• W2938930184 hasConcept C2781467277 @default.
• W2938930184 hasConcept C55493867 @default.
• W2938930184 hasConcept C71924100 @default.
• W2938930184 hasConcept C98274493 @default.
• W2938930184 hasConceptScore W2938930184C104317684 @default.
• W2938930184 hasConceptScore W2938930184C126322002 @default.
• W2938930184 hasConceptScore W2938930184C134018914 @default.
• W2938930184 hasConceptScore W2938930184C164027704 @default.
• W2938930184 hasConceptScore W2938930184C185592680 @default.
• W2938930184 hasConceptScore W2938930184C2776415932 @default.
• W2938930184 hasConceptScore W2938930184C2776637226 @default.
• W2938930184 hasConceptScore W2938930184C2776914184 @default.
• W2938930184 hasConceptScore W2938930184C2778125326 @default.
• W2938930184 hasConceptScore W2938930184C2778754761 @default.
• W2938930184 hasConceptScore W2938930184C2781467277 @default.
• W2938930184 hasConceptScore W2938930184C55493867 @default.
• W2938930184 hasConceptScore W2938930184C71924100 @default.
• W2938930184 hasConceptScore W2938930184C98274493 @default.
• W2938930184 hasLocation W29389301841 @default.
• W2938930184 hasLocation W29389301842 @default.
• W2938930184 hasOpenAccess W2938930184 @default.
• W2938930184 hasPrimaryLocation W29389301841 @default.
• W2938930184 hasRelatedWork W2042280923 @default.
• W2938930184 hasRelatedWork W2357393049 @default.

• next